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INHIBITION OF SEXUAL DEVELOPMENT IN MALE AND FEMALE RATS TREATED WITH VARIOUS STEROIDS AT THE AGE OF FIVE DAYS

1965; Oxford University Press; Volume: 49; Issue: 2 Linguagem: Inglês

10.1530/acta.0.0490193

1479-683X

Fred A. Kind, A. Folch Pi, M Maqueo, L. Herrera Lasso, A Oriol, Ralph I. Dorfman,

Stress Responses and Cortisol

ABSTRACT The effect of various steroids injected into 5 day old male and female rats was evaluated at the age of 45 days. In the males the degree in which testes and accessory sex tissues were atrophied, and in the females the degree of inhibition of luteinization were the indices. Various synthetic oestrogens were potent inhibitors of sexual development in both sexes while androgens were less active. The activity of several oestrogens in this test does not correlate with oestrogenic potency as measured in the uterotrophic test. Testosterone propionate produced moderate atrophy of testes and accessory sex tissue but spermatogenesis was not impaired.