Adjuvant effects of crystal proteins from a Mexican strain of Bacillus thuringiensis on the mouse humoral response
2007; Elsevier BV; Volume: 35; Issue: 4 Linguagem: Inglês
10.1016/j.biologicals.2007.01.006
ISSN1095-8320
AutoresMáximo E. Román Calderón, Juan Manuel Alcocer-González, Moisés Ármides Franco-Molina, Reyes Silvestre Tamez Guerra, Cristina Rodríguez Padilla,
Tópico(s)Antimicrobial Peptides and Activities
ResumoIn this study, we determined the adjuvant effects of the crystal (Cry) proteins, p130, p98, and p64–62, on the immune response of mice to both sheep red blood cells (SRBC) and ovalbumin (OVA). The administration of p130, p98, and p64–62 Cry proteins to Balb/c mice induced a significant (p < 0.01) increase in the production of anti-SRBC antibody-secreting cells (ASC). The p64–62 Cry proteins demonstrated the best ability to induce the production of IgA and IgG antibodies to SRBC (p < 0.05), and IgM, IgA, and IgG antibodies to OVA (p < 0.05). Additionally, Cry proteins did not produce any side effects associated with their administration to Balb/c mice. We suggest the potential use of the p64–62 Cry proteins as adjuvants for the administration of heterologous antigens.
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