METABOLIC ALKALOSIS IN OBSTRUCTIVE VOMITING Volume Depletion and Balance of Net Acid
1974; Wiley; Volume: 63; Issue: 4 Linguagem: Inglês
10.1111/j.1651-2227.1974.tb04844.x
ISSN1651-2227
AutoresJ. K. DEGN, S. Wamberg, K. Engel, P. Kildeberg,
Tópico(s)Intestinal Malrotation and Obstruction Disorders
ResumoABSTRACT. Degn, J. K., Wamberg, S., Engel, K. and Kildeberg, P. (Departments of Paediatrics, Clinical Chemistry, and Physiology, Odense University, Odense, Denmark). Metabolic alkabsis in obstructive vomiting. Volume depletion and balance of net acid. Acta Paediatr Scand, 63: 537, 1974.—Pre‐operative balances of sodium, potassium, calcium, magnesium, chloride, and phosphorus were determined in eleven infants with hypertrophic pyloric stenosis. Additional measurements included acid‐base status of blood and urine and concentrations of electrolytes in serum. From the balance data, the rate of retention of net acid (NAB), the pre‐operative change in chloride space (AECW), and the effect of extracellular volume expansion on blood “base excess” (BE) were derived. The observed pre‐operative change in blood BE was partitioned in retentional, dilutional, and distributional components by comparing estimates of such components based on known physiological constants with the results of multiple oorrelation analysis involving five predictor variables. The results indicate that the fall in blood BE to the normal range was almost entirely accounted for by volume expansion, and that retained net acid was probably neutralized by skeletal base.
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