Characterization of the nm23-M2, nm23-M3 and nm23-M4 mouse genes: comparison with their human orthologs
2002; Elsevier BV; Volume: 296; Issue: 1-2 Linguagem: Inglês
10.1016/s0378-1119(02)00836-3
ISSN1879-0038
AutoresKarine Massé, Sandrine Dabernat, P Bourbon, Monique Larou, Lilian Amrein, Perrine Barraud, Yves Pérel, María de los Milagros Cámara, Marc Landry, Marie‐Lise Lacombe, J.Y. Daniel,
Tópico(s)Chromatin Remodeling and Cancer
ResumoThe nm23 gene family is thought to be involved in physiopathological processes such as growth, differentiation and cancer promotion, progression or metastasis. We report here the mouse nm23-M3 and nm23-M4 complementary DNA sequences and the genomic cloning, characterization and tissue expression pattern of the nm23-M2, nm23-M3 and nm23-M4 genes, in comparison with their human and rat orthologs and with the human nm23-H1 and mouse nm23-M1 genes. The organization and structure of the members of this gene family are remarkably similar in human and rodents. Accordingly, the striking similarities between the human and mouse nm23 genes enable the use of mouse transgenic and knock-out models for studying the role of nucleoside diphosphate kinase isoforms in human physiopathology.
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