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Protective effects of garcinia kola seed extract against paracetamol-induced hepatotoxicity in rats

1990; Elsevier BV; Volume: 29; Issue: 2 Linguagem: Inglês

10.1016/0378-8741(90)90057-z

1872-7573

A Akintonwa, Ani R. Essien,

Chemotherapy-induced organ toxicity mitigation

The hepatoprotective effect of Garcinia kola seed extract was investigated in rats treated with high doses of paracetamol. The extracts when administered at 100 mg/kg three times a day for five consecutive days reduced paracetamol-(800, 1000, 1200 mg/kg) induced lethality from 50, 90 and 100% to 0, 20 and 40%, respectively. There was a significant reduction in the liver enzymes SGOT and SGPT and histology scores. The hepatoprotective effect of the extract may be due to inhibition of cytochrome P-450 which normally converts paracetamol to the toxic intermediate metabolite N-acetyl-p-benzo-quinoneimine (NAPQI).