Produção Nacional
Revisado por pares
Cytotoxic Activity of Pisosterol, a Triterpene Isolated from Pisolithus tinctorius (Mich.: Pers.) Coker & Couch, 1928
2004; De Gruyter; Volume: 59; Issue: 7-8 Linguagem: Inglês
10.1515/znc-2004-7-812
ISSN1865-7125
AutoresRaquel Carvalho Montenegro, Paula C. Jimenez, Rômulo Augusto Feio Farias, Manoel Andrade‐Neto, Franciglauber Silva Bezerra, Maria Elisabete Amaral de Moraes, Manoel Odorico de Moraes, Cláudia Pessoa, Letícia V. Costa‐Lotufo,
Tópico(s)Enzyme-mediated dye degradation
ResumoAbstract Pisolithus tinctorius (Basidiomycete) is an ectomicorrhizal fungus found in the roots and soil surrounding of many species of eucalyptus and pine trees. The present work verified the cytotoxic potential of pisosterol, a triterpene isolated from P. tinctorius collected in the Northeast region of Brazil, on three different animal cell models: mouse erythrocytes, sea urchin embryos and tumor cells. Pisosterol lacked activity on mouse erythrocytes as well as on the development of sea urchin eggs, but strongly inhibited the growth of all seven tumor cell lines tested, especially the leukemia and melanoma cells (IC 50 of 1.55, 1.84 and 1.65 μg/ ml for CEM, HL-60 and B16, respectively). The results found for pisosterol were compared with those of doxorubicin and etoposide
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