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Pharmaceutical cocrystals: An overview

2011; Elsevier BV; Volume: 419; Issue: 1-2 Linguagem: Inglês

10.1016/j.ijpharm.2011.07.037

1873-3476

Ning Qiao, Mingzhong Li, Walkiria Schlindwein, Nazneen Malek, Angela M. Davies, Gary Trappitt,

Energetic Materials and Combustion

Pharmaceutical cocrystals are emerging as a new class of solid drugs with improved physicochemical properties, which has attracted increased interests from both industrial and academic researchers. In this paper a brief and systematic overview of pharmaceutical cocrystals is provided, with particular focus on cocrystal design strategies, formation methods, physicochemical property studies, characterisation techniques, and recent theoretical developments in cocrystal screening and mechanisms of cocrystal formations. Examples of pharmaceutical cocrystals are also summarised in this paper.