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Prevention and Reversion of Nonalcoholic Steatohepatitis in OB/OB Mice by S-Nitroso-N-Acetylcysteine Treatment

2008; Taylor & Francis; Volume: 27; Issue: 2 Linguagem: Inglês

10.1080/07315724.2008.10719703

ISSN

1541-1087

Autores

Cláudia P. Oliveira, Vicência Mara Rodrigues de Lima, Fernanda Ibanez Simplicio, Francisco García Soriano, Evandro Sobroza de Mello, Heraldo Possolo de Souza, Venâncio Avancini Ferreira Alves, Francisco Rafael Martins Laurindo, Flair José Carrilho, Marcelo G. de Oliveira,

Tópico(s)

Nitric Oxide and Endothelin Effects

Resumo

AbstractObjective: To evaluate the role oral administration of S-nitroso-N-acetylcysteine (SNAC), a NO donor drug, in the prevention and reversion of NASH in two different animal models.Methods: NASH was induced in male ob/ob mice by methionine-choline deficient (MCD) and high-fat (H) diets. Two animal groups received or not SNAC orally for four weeks since the beginning of the treatment. Two other groups were submitted to MCD and H diets for 60 days receiving SNAC only from the 31st to the 60th day.Results: SNAC administration inhibited the development of NASH in all groups, leading to a marked decrease in macro and microvacuolar steatosis and in hepatic lipid peroxidation in the MCD group. SNAC treatment reversed the development of NASH in animals treated for 60 days with MCD or H diets, which received SNAC only from the 31st to the 60th day.Conclusions: Oral administration of SNAC markedly inhibited and reversed NASH induced by MCD and H diets in ob/ob mice.KeywordsNASHoxidative stressS-nitroso-N-acetylcysteinenitric oxide This study was supported in part by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Grant 2004/ 04483-7 and Alves de Queiroz Family Fund Research. FIS holds a graduate studentship from Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq, Grant 140702/2003-2.NotesThis study was supported in part by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Grant 2004/ 04483-7 and Alves de Queiroz Family Fund Research. FIS holds a graduate studentship from Conselho Nacional de Desenvolvimento Cientifico e Tecnológico, CNPq, Grant 140702/2003-2.

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