The effect of the purified major protein factor (α-latrotoxin) of black widow spider venom on the release of acetylcholine and norepinephrine from mouse cerebral cortex slices
1978; Elsevier BV; Volume: 139; Issue: 1 Linguagem: Inglês
10.1016/0006-8993(78)90073-2
ISSN1872-6240
AutoresMu-Chin Tzeng, Philip Siekevitz,
Tópico(s)Nicotinic Acetylcholine Receptors Study
ResumoMolecular toxinology research was initially driven by an interest in the small subset of animal toxins that are lethal to humans. However, the realization that many venomous creatures possess a complex repertoire of bioactive peptide toxins with potential pharmaceutical and agrochemical applications has led to an explosion in the number of new peptide toxins being discovered and characterized. Unfortunately, this increased awareness of peptide-toxin diversity has not been matched by the development of a generic nomenclature that enables these toxins to be rationally classified, catalogued, and compared. In this article, we introduce a rational nomenclature that can be applied to the naming of peptide toxins from spiders and other venomous animals.
Referência(s)