Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Spinal cord transection modifies ileal fluid and electrolyte transport in rats

2008; Elsevier BV; Volume: 139; Issue: 1-2 Linguagem: Inglês

10.1016/j.autneu.2007.12.003

1872-7484

Bruno Amaral Medeiros, Camila Linhares dos Santos, Raimundo C. Palheta, Dário Augusto Ferreira de Queiroz, José Ronaldo Vasconcelos da Graça, Armênio Aguiar dos Santos, F.H. Rola, Aldo Â. M. Lima, Francisco de Assis Aquino Gondim,

Pharmacological Effects and Toxicity Studies

Abstract Spinal cord injury (SCI) is associated with severe autonomic changes, including inhibition of gastrointestinal (GI) motility. GI motility changes are known to affect electrolytes transport and these changes have not been adequately studied after SCI. We studied the ileal permeability to fluid and electrolytes in rats submitted to experimental spinal cord transection (SCT), between T4 and T5, throughout the first week after SCT. SCT increased ileal secretion of Na + ( P <0.05) and decreased the Cl − absorption during the first week post SCI ( P <0.05). Water transport was also significantly altered, leading to increased water secretion following the Na + gradient. Ileal secretion of K + was significantly increased 1 and 7 days after spinal cord injury. To our knowledge, the present findings are the first direct evidence that SCT alters ileal electrolyte transport in rats. Further studies are necessary to evaluate the mechanisms involved in this phenomenon.