Oxidized Low-Density Lipoprotein and Oxidative Stress in the Development of Glomerulosclerosis
2008; Karger Publishers; Volume: 29; Issue: 1 Linguagem: Inglês
10.1159/000151277
ISSN1421-9670
AutoresHyun Soon Lee, Chi Young Song,
Tópico(s)Chronic Kidney Disease and Diabetes
ResumoGlomerulosclerosis frequently complicates most renal diseases and is characterized by mesangial matrix accumulation. Oxidized low-density lipoprotein (Ox-LDL) could induce oxidative stress and profibrotic gene expression in mesangial cells. This article will review our current understanding of the pathogenetic mechanisms of lipid-mediated glomerulosclerosis, emphasizing the fibrogenic signaling cascades triggered by Ox-LDL. In addition, therapeutic strategies to prevent the development of Ox-LDL-mediated glomerulosclerosis will be discussed.
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