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Bradykinin Potentiating Factor

1971; Elsevier BV; Volume: 59; Issue: 5 Linguagem: Inglês

10.1378/chest.59.5_supplement.9s

1931-3543

Lewis Joel Greene, S. H. Ferreira, John M. Stewart,

Biochemical and Structural Characterization

The venom of the Brazilian snake Bothrops jararaca contains a mixture of polypeptides, bradykinin potentiating factor, which potentiates the pharmacologic actions of bradykinin in vitro as well as in vivo.1 We have isolated nine biologically active peptides from the venom by ultrafiltration and column chromatographic procedures.2 The peptides contain 5–13 amino acid residues per molecule and have molecular weights in the range 600-1400. They have a high proline content (20-40 mole percent) and each has the cyclized form of glutamic acid (pyrrolidone carboxylic acid) as the amino terminus.