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Steady‐State Bioavailability of Two Clorazepate Dipotassium Dosage Forms

1977; Wiley; Volume: 17; Issue: 1 Linguagem: Inglês

10.1002/j.1552-4604.1977.tb04582.x

1552-4604

P. J. CARRIGAN, George Chao, William M. Barker, Daniël J. Hoffman, Alexander Chun,

Pharmaceutical studies and practices

The Journal of Clinical PharmacologyVolume 17, Issue 1 p. 18-28 Steady-State Bioavailability of Two Clorazepate Dipotassium Dosage Forms P. J. CARRIGAN Ph.D., Corresponding Author P. J. CARRIGAN Ph.D. Pharmaceutical Products Division, Abbott Laboratories, North Chicago, Ill. 60064.Ph.D., Abbott Laboratories, D-493, North Chicago, Ill. 60064.Search for more papers by this authorG. C. CHAO Ph.D., G. C. CHAO Ph.D. Pharmaceutical Products Division, Abbott Laboratories, North Chicago, Ill. 60064.Search for more papers by this authorW. M. BARKER Ph.D., W. M. BARKER Ph.D. Pharmaceutical Products Division, Abbott Laboratories, North Chicago, Ill. 60064.Search for more papers by this authorD. J. HOFFMAN Ph.D., D. J. HOFFMAN Ph.D. Pharmaceutical Products Division, Abbott Laboratories, North Chicago, Ill. 60064.Search for more papers by this authorA. H. C. CHUN Ph.D., A. H. C. CHUN Ph.D. Pharmaceutical Products Division, Abbott Laboratories, North Chicago, Ill. 60064.Search for more papers by this author P. J. CARRIGAN Ph.D., Corresponding Author P. J. CARRIGAN Ph.D. Pharmaceutical Products Division, Abbott Laboratories, North Chicago, Ill. 60064.Ph.D., Abbott Laboratories, D-493, North Chicago, Ill. 60064.Search for more papers by this authorG. C. CHAO Ph.D., G. C. CHAO Ph.D. Pharmaceutical Products Division, Abbott Laboratories, North Chicago, Ill. 60064.Search for more papers by this authorW. M. BARKER Ph.D., W. M. BARKER Ph.D. Pharmaceutical Products Division, Abbott Laboratories, North Chicago, Ill. 60064.Search for more papers by this authorD. J. HOFFMAN Ph.D., D. J. HOFFMAN Ph.D. Pharmaceutical Products Division, Abbott Laboratories, North Chicago, Ill. 60064.Search for more papers by this authorA. H. C. CHUN Ph.D., A. H. C. CHUN Ph.D. Pharmaceutical Products Division, Abbott Laboratories, North Chicago, Ill. 60064.Search for more papers by this author First published: January 1977 https://doi.org/10.1002/j.1552-4604.1977.tb04582.xCitations: 17AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Bliding, A.: Effects of different rates of absorption of two benzodiazepines on subjective and objective parameters. Eur. J. Clin. Pharmacol. 7: 201 (1974). 2 Ghoneim, M. M., Mewaldt, S. P., and Ambre, J.: Plasma levels of diazepam and mood ratings. Anesth. Analg. 54: 173 (1975). 3 Hoffman, D. J., and Chun, A. H. C.: GLC determination of plasma drug levels after oral administration of clorazepate potassium salts. J. Pharm. Sci. 64: 1668 (1975). 4 Chao, G. C., and Michelli, F. A.: Modification of the crossover design for steady-state comparative bioavailability trials. Biometrics 31: 1001 (1975). 5 Metzler, C. M.: Technical Report 7292/69/7292/005. Kalamazoo, Mich., The Upjohn Co., 1969. 6 Gibaldi, M., and Perrier, D.: Pharmacokinetics. New York, Marcel Dekker, 1975, pp. 80–84. 7 Wagner, J. G.: Biopharmaceutics and Relevant Pharmacokinetics. Hamilton, Ill., Drug Intelligence Publications, 1971, p. 293. 8 Hillestad, L., Hansen, T., and Melsom, H.: Diazepam metabolism in normal man: II. Serum concentrations and clinical effect after oral administration and cumulation. Clin. Pharmacol. Therap. 16: 485 (1974). 9 Kaplan, S. A., Jack, M. L., Alexander, K., and Weinfeld, R. E.: Pharmacokinetic profile of diazepam in man following single intravenous and oral and chronic oral administration. J. Pharm. Sci. 62: 1789 (1973). 10 Booker, H. E.: Clorazepate dipotassium in the treatment of intractable epilepsy. J.A.M.A. 229: 552 (1974). Citing Literature Volume17, Issue1January 1977Pages 18-28 ReferencesRelatedInformation