Direct and Convenient Conversion of Alcohols to Fluorides
2004; American Chemical Society; Volume: 6; Issue: 9 Linguagem: Inglês
10.1021/ol049672a
ISSN1523-7060
AutoresJingjun Yin, Devin S. Zarkowsky, David W. Thomas, Matthew M. Zhao, Mark A. Huffman,
Tópico(s)Oxidative Organic Chemistry Reactions
Resumo[reaction: see text] Directly mixing primary, secondary, and tertiary alcohols with nC(4)F(9)SO(2)F-NR(3)(HF)(3)-NR(3) in THF or MeCN results in convenient conversion to the corresponding fluorides in high yields. The readily available reagents are easy to handle, and the mild, almost neutral reaction conditions allow for excellent functional group compatibility. A NR(3)(HF)(3)/NR(3) ratio of </=1:2 gives the highest reactivity.
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