Portal de Periódicos da CAPES

Electrospinning Preparation and Drug‐Delivery Properties of an Up‐conversion Luminescent Porous NaYF 4 :Yb 3+ , Er 3+ @Silica Fiber Nanocomposite

2011; Wiley; Volume: 21; Issue: 12 Linguagem: Inglês

10.1002/adfm.201100193

1616-3028

Zhiyao Hou, Chunxia Li, Ping’an Ma, Guogang Li, Ziyong Cheng, Chong Peng, Dongmei Yang, Piaoping Yang, Jun Lin,

Lanthanide and Transition Metal Complexes

Abstract Up‐conversion (UC) luminescent porous silica fibers decorated with NaYF 4 :Yb 3+ , Er 3+ nanocrystals (NCs) (denoted as NaYF 4 :Yb 3+ , Er 3+ @silica fiber) are prepared by the electrospinning process using cationic surfactant P123 as a template. Monodisperse and hydrophobic oleic acid capped β‐NaYF 4 : Yb 3+ , Er 3+ NCs are prepared by thermal decomposition methodology. Then, these NCs are transferred into aqueous solution by employing cetyltrimethylammonium bromide (CTAB) as secondary surfactant. The water‐dispersible β‐NaYF 4 :Yb 3+ , Er 3+ NCs are dispersed into precursor electrospinning solution containing P123 and tetraethyl orthosilicate (TEOS), followed by preparation of precursor fibers via electrospinning. Finally, porous α‐NaYF 4 :Yb 3+ , Er 3+ @silica fiber nanocomposites are obtained after annealing the precursor fibers containing β‐NaYF 4 :Yb 3+ , Er 3+ at 550 °C. The as‐prepared α‐NaYF 4 :Yb 3+ , Er 3+ @silica fiber possesses porous structure and UC luminescence properties simultaneously. Furthermore, the obtained nanocomposites can be used as a drug delivery host carrier and drug storage/release properties are investigated, using ibuprofen (IBU) as a model drug. The results indicate that the IBU–loaded α‐NaYF 4 :Yb 3+ , Er 3+ @silica fiber nanocomposites show UC emission of Er 3+ under 980 nm NIR laser excitation and a controlled release property for IBU. Meanwhile, the UC emission intensity of IBU–α‐NaYF 4 :Yb 3+ , Er 3+ @silica fiber system varies with the released amount of IBU.