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Catalytic Enantioselective Conia-Ene Reaction

2005; American Chemical Society; Volume: 127; Issue: 49 Linguagem: Inglês

10.1021/ja055059q

1943-2984

Britton K. Corkey, F. Dean Toste,

Synthetic Organic Chemistry Methods

An enantioselective intramolecular Conia-ene reaction of beta-dicarbonyl compounds and alkynes to afford methylene cyclopentanes is described. The reaction employs a DTBMSegphos-Pd(II)/Yb(III) dual catalyst system that allows for the asymmetric synthesis of all-carbon quaternary centers and generates a product containing an alkene that can be further manipulated.