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Synthesis of the Alleged Structure of Sclerophytin A. The Setting of Two Oxygen Bridges within the Fused Cyclodecanol B Ring Is Not Nature's Way

2000; American Chemical Society; Volume: 2; Issue: 13 Linguagem: Inglês

10.1021/ol000083o

1523-7060

Leo A. Paquette, Oscar Moradei, Patrick Bernardelli, Tim Lange,

Traditional and Medicinal Uses of Annonaceae

The structure attributed to sclerophytin A, a cytotoxic soft coral metabolite, was synthesized in an enantioselective manner from (5S)-5-(d-menthyloxy)-2(5H)-furanone. The spectral properties and polarity of the synthetic product require that the structural assignment to the natural material be revised.