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Second generation of α-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical, and biological characterization

2007; Elsevier BV; Volume: 15; Issue: 18 Linguagem: Inglês

10.1016/j.bmc.2007.06.019

1464-3391

Gloria V. López, Fabiana Blanco, Paola Hernández, Ana M. Ferreira, Oscar E. Piro, Carlos Batthyány, Mercedes González, Homero Rubbo, Hugo Cerecetto,

Cardiovascular, Neuropeptides, and Oxidative Stress Research

Synthesis, physicochemical, and biological characterization of a series of α-tocopherol mimetics with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and mammal cytotoxic activities. The lipophilic–hydrophilic balance of all products was also evaluated. A new hybrid furoxan, phenol derivative 17, possesses adequate profile of the studied properties.