A study of the effect of an oral contraceptive on blood coagulation factors, platelets and fibrinolytic activity
1974; Elsevier BV; Volume: 9; Issue: 4 Linguagem: Inglês
10.1016/0010-7824(74)90081-x
ISSN1879-0518
AutoresI. Medhat, Hussein K. Toppozada, Mohammed A. Rizk, Mohammed M. Khowessah, Aziz T.Abdel Malek, M. Moghazi,
Tópico(s)Coagulation, Bradykinin, Polyphosphates, and Angioedema
ResumoAbstract Blood coagulation factors I, II, VII, VIII and X were assayed before and after the intake of combination steroid contraceptive tablets containing 1 mg norethindrone acetate and 0.05 mg ethinyl estradiol, for six months, and also after their long-term use for two or more years. In both groups, there was a significant increase in factors I, II, VII and X, while factor VIII (antihaemophilia globulin) showed no significant change. Platelet count and bleeding time showed no change, but platelet adhesiveness was increased. There was also shortening of the euglobulin lysis time, which means an increased activity of fibrinolytic stimulants.
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