Portal de Periódicos da CAPES

Premature progesterone elevation spares blastulation but not pregnancy rates in in vitro fertilization with coculture

1997; Elsevier BV; Volume: 68; Issue: 4 Linguagem: Inglês

10.1016/s0015-0282(97)80464-5

1556-5653

Rénato Fanchin, Ariel Hourvitz, F. Olivennes, Julien Taı̈eb, A. Hazout, René Frydman,

Gynecological conditions and treatments

To clarify whether embryo development to the blastocyst stage may be affected by premature P elevation during controlled ovarian hyperstimulation (COH) for IVF-ET with embryo coculture.Retrospective study.Tertiary care infertility center.One hundred thirty-one women undergoing 153 IVF-ET cycles with embryo coculture.Patients underwent COH with GnRH agonist and hMG. Embryos were cocultured up to the blastocyst stage. According to plasma P levels on the day of hCG, two groups were defined: low P (P < or = 0.9 ng/mL; conversion factor to SI unit, 3.180) and high P (P > 0.9 ng/mL).Blastulation (number of blastocysts/number of noncavitating embryos x 100) and pregnancy rates (PRs).Blastulation rates were similar in the low and high P groups (51% and 48%, respectively). Moreover, patients included in the high P groups achieved significantly lower clinical and ongoing PRs (12% versus 29% and 7% versus 25%, respectively).The lack of difference in blastulation rates between the groups further supports the hypothesis that premature P elevation does not alter oocyte and embryo quality. Hence, the observed decrease in PRs is likely to reflect impaired endometrial receptivity in the high P group.