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The Need for Adequate Coverage of Oncology Topics in Internal Medicine Journals

2008; Elsevier BV; Volume: 83; Issue: 9 Linguagem: Inglês

10.4065/83.9.980

1942-5546

Ayalew Tefferi,

Multiple and Secondary Primary Cancers

In 2008, approximately 1.5 million new cancer cases are projected to occur in the United States.1Jemal A Siegel R Ward E et al.Cancer statistics, 2008.CA Cancer J Clin. 2008 Mar-Apr; 58 (Epub 2008 Feb 20.): 71-96Crossref PubMed Scopus (10205) Google Scholar The annual figure worldwide is estimated at more than 10 million.2Shibuya K Mathers CD Boschi-Pinto C Lopez AD Murray CJ Global and regional estimates of cancer mortality and incidence by site, II: results for the global burden of disease 2000.BMC Cancer. 2002 Dec 26; 2 (Epub 2002 Dec 26.): 37Crossref PubMed Scopus (352) Google Scholar In the United States alone, more than 500,000 cancer deaths are reported each year, making cancer one of the 2 leading causes of death, along with heart disease. In 2005, cancer and heart disease accounted for approximately 23% and 27% of all deaths, respectively.1Jemal A Siegel R Ward E et al.Cancer statistics, 2008.CA Cancer J Clin. 2008 Mar-Apr; 58 (Epub 2008 Feb 20.): 71-96Crossref PubMed Scopus (10205) Google Scholar Given the number of patients with active cancer or with the downstream medical problems seen in cancer survivors, it is reasonable to argue that medical oncology topics should be given increasing coverage in internal medicine journals. Such was the spirit that led Mayo Clinic Proceedings to publish back-to-back treatment symposia3Adjei AA Rajkumar SV Tefferi A Cancer symposium for the practitioner: introduction to solid tumors.Mayo Clin Proc. 2007; 82: 107-109Abstract Full Text Full Text PDF PubMed Scopus (7) Google Scholar, 4Tefferi A Rajkumar SV Adjei AA Introduction to a cancer symposium for the practitioner.Mayo Clin Proc. 2005; 80: 1085-1086Abstract Full Text Full Text PDF PubMed Scopus (5) Google Scholar in hematologic malignancies5Yee KWL O'Brien SM Chronic lymphocytic leukemia: diagnosis and treatment.Mayo Clin Proc. 2006; 81: 1105-1129Abstract Full Text Full Text PDF PubMed Scopus (56) Google Scholar, 6Quintas-Cardama A Cortes JE Chronic myeloid leukemia: diagnosis and treatment.Mayo Clin Proc. 2006; 81: 973-988Abstract Full Text Full Text PDF PubMed Scopus (161) Google Scholar, 7Halfdanarson TR Hogan WJ Moynihan TJ Oncologic emergencies: diagnosis and treatment.Mayo Clin Proc. 2006; 81: 835-848Abstract Full Text Full Text PDF PubMed Scopus (74) Google Scholar, 8Rajkumar SV Dispenzieri A Kyle RA Monoclonal gammopathy of undetermined significance, Waldenstrom macroglobulinemia, AL amyloidosis, and related plasma cell disorders: diagnosis and treatment.Mayo Clin Proc. 2006; 81: 693-703Abstract Full Text Full Text PDF PubMed Scopus (159) Google Scholar, 9Tefferi A Elliott MA Pardanani A Atypical myeloproliferative disorders: diagnosis and management.Mayo Clin Proc. 2006; 81: 553-563Abstract Full Text Full Text PDF PubMed Scopus (47) Google Scholar, 10Ansell SM Armitage JO Hodgkin lymphoma: diagnosis and treatment.Mayo Clin Proc. 2006; 81: 419-426Abstract Full Text Full Text PDF PubMed Scopus (44) Google Scholar, 11Jabbour EJ Estey E Kantarjian HM Adult acute myeloid leukemia: diagnosis and treatment.Mayo Clin Proc. 2006; 81: 247-260Abstract Full Text Full Text PDF PubMed Scopus (97) Google Scholar, 12Steensma DP Bennett JM The myelodysplastic syndromes: diagnosis and treatment.Mayo Clin Proc. 2006; 81: 104-130Abstract Full Text Full Text PDF PubMed Scopus (160) Google Scholar, 13Ravandi F O'Brien S Chronic lymphoid leukemias other than chronic lymphocytic leukemia: diagnosis and treatment.Mayo Clin Proc. 2005; 80: 1660-1674Abstract Full Text Full Text PDF PubMed Scopus (29) Google Scholar, 14Jabbour EJ Faderl S Kantarjian HM Adult acute lymphoblastic leukemia.Mayo Clin Proc. 2005; 80: 1517-1527Abstract Full Text Full Text PDF PubMed Scopus (103) Google Scholar, 15Rajkumar SV Kyle RA Multiple myeloma: diagnosis and treatment.Mayo Clin Proc. 2005; 80: 1371-1382Abstract Full Text Full Text PDF PubMed Scopus (209) Google Scholar, 16Tefferi A Barbui T bcr/abl-negative, classic myeloproliferative disorders: diagnosis and treatment.Mayo Clin Proc. 2005; 80: 1220-1232Abstract Full Text Full Text PDF PubMed Scopus (37) Google Scholar, 17Ansell SM Armitage J Non-Hodgkin lymphoma: diagnosis and treatment.Mayo Clin Proc. 2005; 80: 1087-1097Abstract Full Text Full Text PDF PubMed Scopus (125) Google Scholar and solid tumor18Sekulic A Haluska Jr, P Miller AJ Melanoma Study Group of the Mayo Clinic Cancer Center et al.Malignant melanoma in the 21st century: the emerging molecular landscape.Mayo Clin Proc. 2008; 83: 825-846Abstract Full Text Full Text PDF PubMed Scopus (105) Google Scholar, 19Khushalani NI Cancer of the esophagus and stomach.Mayo Clin Proc. 2008; 83: 712-722PubMed Scopus (68) Google Scholar, 20Molina JR Yang P Cassivi SD Schild SE Adjei AA Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship.Mayo Clin Proc. 2008; 83: 584-594PubMed Scopus (2580) Google Scholar, 21Marur S Forastiere AA Head and neck cancer: changing epidemiology, diagnosis, and treatment.Mayo Clin Proc. 2008; 83: 489-501Abstract Full Text Full Text PDF PubMed Scopus (521) Google Scholar, 22Sher T Dy GK Adjei AA Small cell lung cancer.Mayo Clin Proc. 2008; 83: 355-367Abstract Full Text Full Text PDF PubMed Scopus (347) Google Scholar, 23Bakkum-Gamez JN Gonzalez-Bosquet J Laack NN Mariani A Dowdy SC Current issues in the management of endometrial cancer.Mayo Clin Proc. 2008; 83: 97-112Abstract Full Text Full Text PDF PubMed Scopus (118) Google Scholar, 24Long III, HJ Laack NNI Gostout BS Prevention, diagnosis, and treatment of cervical cancer.Mayo Clin Proc. 2007; 82: 1566-1574Abstract Full Text Full Text PDF PubMed Scopus (5) Google Scholar, 25Skubitz KM D'Adamo DR Sarcoma.Mayo Clin Proc. 2007; 82: 1409-1432Abstract Full Text Full Text PDF PubMed Scopus (221) Google Scholar, 26Buckner JC Brown PD O'Neill BP Meyer FB Wetmore CJ Uhm JH Central nervous system tumors.Mayo Clin Proc. 2007; 82: 1271-1286Abstract Full Text Full Text PDF PubMed Scopus (227) Google Scholar, 27Pruthi S Boughey JC Brandt KR et al.A multidisciplinary approach to the management of breast cancer, part 2: therapeutic considerations.Mayo Clin Proc. 2007; 82: 1131-1140Abstract Full Text Full Text PDF PubMed Scopus (26) Google Scholar, 28Pruthi S Brandt KR Degnim AC et al.A multidisciplinary approach to the management of breast cancer, part 1: prevention and diagnosis.Mayo Clin Proc. 2007; 82: 999-1012Abstract Full Text Full Text PDF PubMed Scopus (42) Google Scholar, 29Kademani D Oral cancer.Mayo Clin Proc. 2007; 82: 878-887Abstract Full Text Full Text PDF PubMed Scopus (271) Google Scholar, 30Aletti GD Gallenberg MM Cliby WA Jatoi A Hartmann LC Current management strategies for ovarian cancer.Mayo Clin Proc. 2007; 82: 751-770PubMed Scopus (174) Google Scholar, 31Alberts SR Gores GJ Kim GP et al.Treatment options for hepatobiliary and pancreatic cancer.Mayo Clin Proc. 2007; 82: 628-637Abstract Full Text Full Text PDF PubMed Scopus (53) Google Scholar, 32Markovic SN Erickson LA Rao RD Melanoma Study Group of the Mayo Clinic Cancer Center et al.Malignant melanoma in the 21st century, part 2: staging, prognosis, and treatment.Mayo Clin Proc. 2007; 82: 490-513Abstract Full Text Full Text PDF PubMed Scopus (114) Google Scholar, 33Markovic SN Erickson LA Rao RD Melanoma Study Group of the Mayo Clinic Cancer Center et al.Malignant melanoma in the 21st century, part 1: epidemiology, risk factors, screening, prevention, and diagnosis.Mayo Clin Proc. 2007; 82: 364-380PubMed Scopus (375) Google Scholar, 34Walczak JR Carducci MA Prostate cancer: a practical approach to current management of recurrent disease.Mayo Clin Proc. 2007; 82: 243-249PubMed Scopus (59) Google Scholar, 35Gill S Blackstock WA Goldberg RM Colorectal cancer.Mayo Clin Proc. 2007; 82: 114-129PubMed Scopus (57) Google Scholar, 36Chandra V Allen MS Nichols III, FC Deschamps C Cassivi SD Pairolero PC The role of pulmonary resection in small cell lung cancer.Mayo Clin Proc. 2006; 81: 619-624Abstract Full Text Full Text PDF PubMed Scopus (27) Google Scholar between August 2005 and July 2008. The completion of these symposia is only the “end of the beginning” in the journal's concerted and structured effort to serve community-based oncologists with current diagnostic and management algorithms. During the same period, the journal has published a substantial number of other original articles, reviews, and editorials that are directly relevant to oncology.37Perez EA Koehler M Byrne J Preston AJ Rappold E Ewer MS Cardiac safety of lapatinib: pooled analysis of 3689 patients enrolled in clinical trials.Mayo Clin Proc. 2008; 83: 679-686PubMed Scopus (325) Google Scholar, 38Pardanani A Lasho TL Hussein K et al.JAK2V617F mutation screening as part of the hypercoagulable work-up in the absence of splanchnic venous thrombosis or overt myeloproliferative neoplasm: assessment of value in a series of 664 consecutive patients.Mayo Clin Proc. 2008; 83: 457-459Abstract Full Text Full Text PDF PubMed Scopus (46) Google Scholar, 39Heffner JE Klein JS Recent advances in the diagnosis and management of malignant pleural effusions.Mayo Clin Proc. 2008; 83: 235-250PubMed Scopus (173) Google Scholar, 40Bernheim AM Connolly HM Rubin J et al.Role of hepatic resection for patients with carcinoid heart disease.Mayo Clin Proc. 2008; 83: 143-150PubMed Scopus (38) Google Scholar, 41Iwanaga M Tagawa M Tsukasaki K Kamihira S Tomonaga M Prevalence of monoclonal gammopathy of undetermined significance: study of 52,802 persons in Nagasaki City, Japan.Mayo Clin Proc. 2007; 82: 1474-1479Abstract Full Text Full Text PDF PubMed Scopus (8) Google Scholar, 42Landgren O Katzmann JA Hsing AW et al.Prevalence of monoclonal gammopathy of undetermined significance among men in Ghana.Mayo Clin Proc. 2007; 82: 1468-1473Abstract Full Text Full Text PDF PubMed Scopus (12) Google Scholar, 43Munshi NC Monoclonal gammopathy of undetermined significance: genetic vs environmental etiologies [editorial].Mayo Clin Proc. 2007; 82: 1457-1459Abstract Full Text Full Text PDF PubMed Scopus (12) Google Scholar, 44Tefferi A Pharmaceutical erythropoietin use in patients with cancer: is it time to abandon ship or just drop anchor [editorial]?.Mayo Clin Proc. 2007; 82: 1316-1318Abstract Full Text Full Text PDF PubMed Scopus (11) Google Scholar, 45Gandhi GY Basu R Dispenzieri A Basu A Montori VM Brennan MD Endocrinopathy in POEMS syndrome: the Mayo Clinic experience.Mayo Clin Proc. 2007; 82: 836-842Abstract Full Text Full Text PDF PubMed Scopus (89) Google Scholar, 46Witzig TE Inwards DJ Habermann TM et al.Treatment of benign orbital pseudolymphomas with the monoclonal anti-CD20 antibody rituximab.Mayo Clin Proc. 2007; 82: 692-699Abstract Full Text Full Text PDF PubMed Scopus (34) Google Scholar, 47Tefferi A Pardanani A Evaluation of “increased” hemoglobin in the JAK2 mutations era: a diagnostic algorithm based on genetic tests.Mayo Clin Proc. 2007; 82: 599-604Abstract Full Text Full Text PDF PubMed Scopus (27) Google Scholar, 48Nowakowski GS Hoyer JD Shanafelt TD et al.Using smudge cells on routine blood smears to predict clinical outcome in chronic lymphocytic leukemia: a universally available prognostic test.Mayo Clin Proc. 2007; 82: 449-453Abstract Full Text Full Text PDF PubMed Scopus (39) Google Scholar, 49Rosinol L Cibeira MT Montoto S et al.Monoclonal gammopathy of undetermined significance: predictors of malignant transformation and recognition of an evolving type characterized by a progressive increase in M protein size.Mayo Clin Proc. 2007; 82: 428-434Abstract Full Text Full Text PDF PubMed Scopus (75) Google Scholar, 50Tollefson MK Slezak JM Leibovich BC Zincke H Blute ML Stratification of patient risk based on prostate-specific antigen doubling time after radical retropubic prostatectomy.Mayo Clin Proc. 2007; 82: 422-427Abstract Full Text Full Text PDF PubMed Scopus (26) Google Scholar, 51Dispenzieri A Rajkumar SV Gertz MA et al.Treatment of newly diagnosed multiple myeloma based on Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART): consensus statement.Mayo Clin Proc. 2007; 82: 323-341PubMed Scopus (175) Google Scholar, 52Lonial S Designing risk-adapted therapy for multiple myeloma: the Mayo perspective [editorial].Mayo Clin Proc. 2007; 82: 279-281PubMed Scopus (5) Google Scholar, 53Midthun DE Swensen SJ Hartman TE Jett JR Lung cancer screening results: easily misunderstood [editorial].Mayo Clin Proc. 2007; 82: 14-15PubMed Scopus (5) Google Scholar, 54Kahlenborn C Modugno F Potter DM Severs WB Oral contraceptive use as a risk factor for premenopausal breast cancer: a meta-analysis.Mayo Clin Proc. 2006; 81: 1290-1302Abstract Full Text Full Text PDF PubMed Scopus (168) Google Scholar, 55Cerhan JR Oral contraceptive use and breast cancer risk: current status [editorial].Mayo Clin Proc. 2006; 81: 1287-1289Abstract Full Text Full Text PDF PubMed Scopus (9) Google Scholar, 56Kademani D Koka S Lacy MQ Rajkumar SV Primary surgical therapy for osteonecrosis of the jaw secondary to bisphosphonate therapy.Mayo Clin Proc. 2006; 81: 1100-1103Abstract Full Text Full Text PDF PubMed Scopus (73) Google Scholar, 57Lacy MQ Dispenzieri A Gertz MA et al.Mayo Clinic consensus statement for the use of bisphosphonates in multiple myeloma.Mayo Clin Proc. 2006; 81: 1047-1053Abstract Full Text Full Text PDF PubMed Scopus (212) Google Scholar, 58Lacy MQ Multiple myeloma: new options, new challenges [editorial].Mayo Clin Proc. 2006; 81: 877-879Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar, 59Vesole DH Perez WS Akasheh M Boudreau C Reece DE Bredeson CN Plasma Cell Disorders Working Committee of the Center for International Blood and Marrow Transplant Research High-dose therapy and autologous hematopoietic stem cell transplantation for patients with primary systemic amyloidosis: a Center for International Blood and Marrow Transplant Research Study.Mayo Clin Proc. 2006; 81: 880-888Abstract Full Text Full Text PDF PubMed Scopus (56) Google Scholar, 60Gertz MA Autologous attack on amyloidosis [editorial].Mayo Clin Proc. 2006; 81: 874-876Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar, 61Sideras K Schaefer PL Okuno SH et al.Low-molecular-weight heparin in patients with advanced cancer: a phase 3 clinical trial.Mayo Clin Proc. 2006; 81: 758-767Abstract Full Text Full Text PDF PubMed Scopus (147) Google Scholar, 62Liang KV Sanderson SO Nowakowski GS Arora AS Metastatic malignant melanoma of the gastrointestinal tract.Mayo Clin Proc. 2006; 81: 511-516Abstract Full Text Full Text PDF PubMed Scopus (114) Google Scholar, 63Cummins DL Cummins JM Pantle H Silverman MA Leonard AL Chanmugam A Cutaneous malignant melanoma.Mayo Clin Proc. 2006; 81: 500-507Abstract Full Text Full Text PDF PubMed Scopus (241) Google Scholar, 64Mauro MJ Maziarz RT Stem cell transplantation in patients with chronic myelogenous leukemia: when should it be used?.Mayo Clin Proc. 2006; 81: 404-416Abstract Full Text Full Text PDF PubMed Scopus (12) Google Scholar, 65Tefferi A Iron chelation therapy for myelodysplastic syndrome: if and when.Mayo Clin Proc. 2006; 81: 197-198Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar, 66Wolanskyj AP Schwager SM McClure RF Larson DR Tefferi A Essential thrombocythemia beyond the first decade: life expectancy, long-term complication rates, and prognostic factors.Mayo Clin Proc. 2006; 81: 159-166Abstract Full Text Full Text PDF PubMed Scopus (281) Google Scholar, 67Campbell PJ Green AR The long-term outlook for essential thrombocythemia [editorial].Mayo Clin Proc. 2006; 81: 157-158Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar, 68Rajkumar SV Thalidomide therapy and deep venous thrombosis in multiple myeloma [editorial].Mayo Clin Proc. 2005; 80: 1549-1551Abstract Full Text Full Text PDF PubMed Scopus (67) Google Scholar, 69Trieu Y Trudel S Pond GR et al.Weekly cyclophosphamide and alternate-day prednisone: an effective, convenient, and well-tolerated oral treatment for relapsed multiple myeloma after autologous stem cell transplantation.Mayo Clin Proc. 2005; 80: 1578-1582Abstract Full Text Full Text PDF PubMed Scopus (27) Google Scholar, 70Baz R Li L Kottke-Marchant K et al.The role of aspirin in the prevention of thrombotic complications of thalidomide and anthracycline-based chemotherapy for multiple myeloma.Mayo Clin Proc. 2005; 80: 1568-1574Abstract Full Text Full Text PDF PubMed Scopus (210) Google Scholar, 71Ecker RD Endo T Wetjen NM Krauss WE Diagnosis and treatment of vertebral column metastases.Mayo Clin Proc. 2005; 80: 1177-1186Abstract Full Text Full Text PDF PubMed Scopus (98) Google Scholar, 72Bundrick JB Cook DA Gostout BS Screening for cervical cancer and initial treatment of patients with abnormal results from papanicolaou testing.Mayo Clin Proc. 2005; 80: 1063-1068Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar, 73Tefferi A Gilliland DG The JAK2V617F tyrosine kinase mutation in myeloproliferative disorders: status report and immediate implications for disease classification and diagnosis.Mayo Clin Proc. 2005; 80: 947-958Abstract Full Text Full Text PDF PubMed Scopus (113) Google Scholar, 74Kumar N Elliott MA Hoyer JD Harper Jr, CM Ahlskog JE Phyliky RL “Myelodysplasia,” myeloneuropathy, and copper deficiency.Mayo Clin Proc. 2005; 80: 943-946Abstract Full Text Full Text PDF PubMed Scopus (60) Google Scholar, 75Pisansky TM External beam radiotherapy as curative treatment of prostate cancer.Mayo Clin Proc. 2005; 80: 883-898Abstract Full Text Full Text PDF PubMed Scopus (9) Google Scholar, 76Burke JP Hay ID Dignan F et al.Long-term trends in thyroid carcinoma: a population-based study in Olmsted County, Minnesota, 1935-1999.Mayo Clin Proc. 2005; 80: 753-758PubMed Google Scholar, 77Tebben PJ Kalli KR Cliby WA et al.Elevated fibroblast growth factor 23 in women with malignant ovarian tumors.Mayo Clin Proc. 2005; 80: 745-751PubMed Google Scholar, 78Steensma DP List AF Genetic testing in the myelodysplastic syndromes: molecular insights into hematologic diversity.Mayo Clin Proc. 2005; 80: 681-698Abstract Full Text Full Text PDF PubMed Scopus (48) Google Scholar, 79Tefferi A Dewald GW Litzow ML et al.Chronic myeloid leukemia: current application of cytogenetics and molecular testing for diagnosis and treatment.Mayo Clin Proc. 2005; 80: 390-402Abstract Full Text Full Text PDF PubMed Scopus (55) Google Scholar, 80Tefferi A Blood eosinophilia: a new paradigm in disease classification, diagnosis, and treatment.Mayo Clin Proc. 2005; 80: 75-83PubMed Google Scholar, 81Rhodes DJ O'Connor MK Phillips SW Smith RL Collins DA Molecular breast imaging: a new technique using technetium Tc 99m scintimammography to detect small tumors of the breast.Mayo Clin Proc. 2005; 80: 24-30Abstract PubMed Scopus (84) Google Scholar, 82Tefferi A The indolent natural history of essential thrombocythemia: a challenge to new drug development.Mayo Clin Proc. 2005; 80: 97-98PubMed Google Scholar Mayo Clinic Proceedings' increasing commitment to cancer medicine is further illustrated by its recent inclusion of 6400 practicing oncologists and hematologists among its circulation of approximately 130,000.83Lanier WL Mayo Clinic Proceedings 2008: content refinement, continuing medical education credit, web site improvements, and more [editorial].Mayo Clin Proc. 2008; 83: 13-16Abstract Full Text Full Text PDF Scopus (3) Google Scholar The journal is poised to intensify its coverage of a wide spectrum of topics in oncology and, in particular, to facilitate the translation of new science into everyday practice.47Tefferi A Pardanani A Evaluation of “increased” hemoglobin in the JAK2 mutations era: a diagnostic algorithm based on genetic tests.Mayo Clin Proc. 2007; 82: 599-604Abstract Full Text Full Text PDF PubMed Scopus (27) Google Scholar Extraordinary progress in biotechnology is enabling scientists to decipher the pathogenesis of cancer and discover new mutations and oncogenic cellular signals that are being exploited as molecular markers of disease and drug targets; in some instances, such progress has resulted in optimization of “targeted” therapy and substitution of complex and dangerous treatment modalities by simple and sometimes oral-only drug therapy.84Sharma SV Settleman J Oncogene addiction: setting the stage for molecularly targeted cancer therapy.Genes Dev. 2007; 21: 3214-3231Crossref PubMed Scopus (343) Google Scholar, 85Druker BJ Tamura S Buchdunger E et al.Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells.Nat Med. 1996; 2: 561-566Crossref PubMed Scopus (3155) Google Scholar, 86Druker BJ Guilhot F O'Brien SG IRIS Investigators et al.Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia.N Engl J Med. 2006; 355: 2408-2417Crossref PubMed Scopus (2896) Google Scholar However, in other instances, oncologists are being inundated by the introduction of many new cancer drugs that are not nearly as effective as they are trumpeted to be. Therefore, it is important to empower community-based oncologists by providing them not only with information regarding the optimal use of effective drugs79Tefferi A Dewald GW Litzow ML et al.Chronic myeloid leukemia: current application of cytogenetics and molecular testing for diagnosis and treatment.Mayo Clin Proc. 2005; 80: 390-402Abstract Full Text Full Text PDF PubMed Scopus (55) Google Scholar but also with practical and unbiased guidelines to help decision making in the context of suboptimal therapeutic choices.51Dispenzieri A Rajkumar SV Gertz MA et al.Treatment of newly diagnosed multiple myeloma based on Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART): consensus statement.Mayo Clin Proc. 2007; 82: 323-341PubMed Scopus (175) Google Scholar Finally, familiarity with the subject matter of oncology is also important to primary care physicians, even if they are not labeled as “oncologists”; their participation in cancer prevention, screening, early detection, and posttreatment monitoring of response and treatment complications is crucial.87Hewitt ME Bamundo A Day R Harvey C Perspectives on post-treatment cancer care: qualitative research with survivors, nurses, and physicians.J Clin Oncol. 2007; 25: 2270-2273Crossref PubMed Scopus (182) Google Scholar Furthermore, with the increasing number of cancer survivors, particularly those of advanced age and with other comorbidities, the challenge of managing the long-term effects of cancer and its treatment cannot be met by oncologists alone.88Aziz NM Bellizzi K Older survivors and cancer care [editorial].J Natl Cancer Inst. 2008 Jan 2; 100 (Epub 2007 Dec 25.): 4-5Crossref PubMed Scopus (10) Google Scholar These are but some of the reasons why an internal medicine journal, such as Mayo Clinic Proceedings, should complement subspecialty oncology journals by disseminating information that is relevant to practical cancer medicine.