Ceramide: A New Lipid “Second Messenger”?
2009; Oxford University Press; Volume: 50; Issue: 3 Linguagem: Inglês
10.1111/j.1753-4887.1992.tb01273.x
ISSN1753-4887
Autores Tópico(s)Lipid Membrane Structure and Behavior
Resumo1-Alpha, 25-dihydroxyvitamin D3, tumor necrosis factor alpha, and gamma-interferon induce sphingomyelin turnover to ceramide in HL-60 cells. The time frame of the turnover is consistent with ceramide formation being a mediator of growth and differentiation; furthermore, differentiation can be induced by addition of exogenous ceramides alone. Hence, the action of the biologically active form of vitamin D and other nutritionally relevant factors may be mediated by lipid second messenger pathways involving sphingolipids.
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