Antispasmodic Effects and Structure−Activity Relationships of Labdane Diterpenoids from Marrubium globosum ssp. libanoticum
2009; American Chemical Society; Volume: 72; Issue: 8 Linguagem: Inglês
10.1021/np9002756
ISSN1520-6025
AutoresDaniela Rigano, Gabriella Aviello, Maurizio Bruno, Carmen Formisano, Sergio Rosselli, Raffaele Capasso, Felice Senatore, Angelo A. Izzo, Francesca Borrelli,
Tópico(s)Phytochemistry and Bioactive Compounds
ResumoMarrubium globosum ssp. libanoticum is a medicinal plant used in Lebanon to reduce pain and smooth muscle spasms. A chloroform extract obtained from M. globosum aerial parts reduced acetylcholine-induced contractions in the isolated mouse ileum. The purification of this extract identified, among 12 isolated labdane diterpenoids, four new compounds, named 13-epicyllenin A (4), 13,15-diepicyllenin A (5), marrulibacetal (9), and marrulactone (11). Their structures were determined by spectroscopic methods. Compound 9, which exerted antispasmodic activity, is likely the active ingredient of the extract. Preliminary structure-activity relationships for this class of compounds are suggested.
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