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Degradation of indole by Alcaligenes spec.

1983; Elsevier BV; Volume: 4; Issue: 2 Linguagem: Inglês

10.1016/s0723-2020(83)80046-0

1618-0984

Günter Claus, H. J. Kutzner,

3D Printing in Biomedical Research

Alcaligenes spec. strain In 3 was isolated from an enrichment culture with indole inoculated with activated sludge. The organism was able to grow with indole as sole source of carbon and nitrogen. During growth with this substrate indigo and anthranilate accumulated in the culture broth. By measurement of the oxidation of intermediates (O2-uptake) and determination of the activity of enzymes responsible for ring cleavage the following pathway for indole degradation could be established: indole → indoxyl → isatin → anthranilate → gentisate → maleyl pyruvate → fumaryl pyruvate → fumarate + pyruvate. — Alcaligenes spec. strain In 3 was also able to grow with various aromatic compounds; these were degraded by ortho- or meta-cleavage or via the gentisinic acid pathway.