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BIBTEX RIS

LTP and activity-dependent synaptogenesis: the more alike they are, the more different they become

1998; Elsevier BV; Volume: 8; Issue: 1 Linguagem: Inglês

10.1016/s0959-4388(98)80017-2

ISSN

1873-6882

Autores

Martha Constantine‐Paton, Hollis T. Cline,

Tópico(s)

Lipid Membrane Structure and Behavior

Resumo

Recent data suggest that long-term potentiation and activity-dependent synaptogenesis share the same mechanism at the initiation stage during which NMDA receptor activity is necessary to increase the postsynaptic response via AMPA receptor currents. However, several fundamental differences between the environments of young and mature synapses and the neurons that support them suggest that the same cellular mechanism is facilitated by very different parameters in the young versus the mature brain.

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