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ALVEOLAR ARTERIAL CO2 DIFFERENCE (AaDCO2) IN RESPIRATORY DISEASES IN THE NEWBORN

1984; Springer Nature; Volume: 18; Linguagem: Inglês

10.1203/00006450-198404001-01885

1530-0447

Tzong Wei, Shyan Sun, Amelia Bautista, Wen Lin,

Respiratory Support and Mechanisms

The purpose of this study is to use AaDCO2 as an index to observe ventilatory function in six different neonatal respiratory diseases, i.e. respiratory distress syndrome (RDS), 2. persistant fetal circulation (PFC), 3. meconium aspiration syndrome (MAS), 4. asphyxia neonatorum (asphyx.), 5. uncomplicated recurrent apneas (apnea), 6. transient tachypnea of newborn (TTN). Foregger End-Tidal CO2 monitoring system was used to determine PETCO2 via endotracheal tube adapter. AaDCO2 (PaCO2-PETCO2) was obtained on the first day of each patient while PaCO2 was controlled at 40±5 torr. All patients were on mechanical ventilator. (Bourns BP 200) Statistical analysis of variance reveals significant difference in AaDCO2 among 6 diseases. (F ratio 17.49, p<0.001). Since AaDCO2 in normal newborn infants is accepted as 3.2, (Sun, et al), it can be inferred that there is little pulmonary ventilatory problem in terms of CO2 excretion in infants with asphyxia, uncomplicated apneas and transient tachypnea of newborn. However there is significant ventilatory problems (inability to excrete CO2) among others in RDS, PFC and MAS.