Highly diastereoselective addition of silyl enolates to chiral imines derived from (S)-valine methyl ester using lanthanide triflate
1996; Elsevier BV; Volume: 37; Issue: 10 Linguagem: Inglês
10.1016/0040-4039(96)00108-6
ISSN1873-3581
AutoresPier Giorgio Cozzi, Bruno Di Simone, Achille Umani‐Ronchi,
Tópico(s)Cancer Treatment and Pharmacology
ResumoOne-pot highly diastereoselective synthesis of β-amino esters, precursors of β-amino acids and β-lactam antibiotics has been accomplished starting from an aldehyde, a chiral amine and a silyl enolate using Yb(OTf)3 as a catalyst at room temperature. Excellent to good levels of diastereoselection have been achieved by the use of (S)-Valine methyl ester as chiral amine.
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