Controversies in Cardiovascular MR Imaging: Reasons Why Imaging Myocardial T2 Has Clinical and Pathophysiologic Value in Acute Myocardial Infarction
2012; Radiological Society of North America; Volume: 265; Issue: 1 Linguagem: Inglês
10.1148/radiol.12112491
ISSN1527-1315
AutoresAndrew E. Arai, Steve Leung, Peter Kellman,
Tópico(s)Acute Myocardial Infarction Research
ResumoHomeRadiologyVol. 265, No. 1 PreviousNext Reviews and CommentaryControversiesControversies in Cardiovascular MR Imaging: Reasons Why Imaging Myocardial T2 Has Clinical and Pathophysiologic Value in Acute Myocardial InfarctionAndrew E. Arai , Steve Leung, Peter KellmanAndrew E. Arai , Steve Leung, Peter KellmanAuthor AffiliationsFrom the Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bldg 10, Room B1D416, MSC 1061, 10 Center Dr, Bethesda, MD 20892-1061 (A.E.A., S.L., P.K.).Address correspondence to A.E.A. (e-mail: [email protected]).Andrew E. Arai Steve LeungPeter KellmanPublished Online:Oct 1 2012https://doi.org/10.1148/radiol.12112491MoreSectionsFull textPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In AbstractMounting evidence indicates that T2-weighted images can be used not only to measure the area at risk but also to refine our understanding of gadoliniumenhanced myocardium in the setting of acute myocardial infarction, as well as the pathophysiology of acute myocardial infarction in general.References1 Kloner RA, Jennings RB. Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 1. Circulation 2001;104(24):2981–2989. Crossref, Medline, Google Scholar2 Aletras AH, Tilak GS, Natanzon A, et al.. Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validations. Circulation 2006;113(15):1865–1870. Crossref, Medline, Google Scholar3 Kiricuta IC, Simplăceanu V. Tissue water content and nuclear magnetic resonance in normal and tumor tissues. Cancer Res 1975;35(5):1164–1167. Medline, Google Scholar4 Higgins CB, Herfkens R, Lipton MJ, et al.. Nuclear magnetic resonance imaging of acute myocardial infarction in dogs: alterations in magnetic relaxation times. Am J Cardiol 1983;52(1):184–188. Crossref, Medline, Google Scholar5 Tilak GS, Hsu LY, Hoyt RF, Arai AE, Aletras AH. In vivo T2-weighted magnetic resonance imaging can accurately determine the ischemic area at risk for 2-day-old nonreperfused myocardial infarction. Invest Radiol 2008;43(1):7–15. Crossref, Medline, Google Scholar6 García-Dorado D, Oliveras J, Gili J, et al.. Analysis of myocardial oedema by magnetic resonance imaging early after coronary artery occlusion with or without reperfusion. Cardiovasc Res 1993;27(8):1462–1469. Crossref, Medline, Google Scholar7 Schwartz Longacre L, Kloner RA, Arai AE, et al.. New horizons in cardioprotection: recommendations from the 2010 National Heart, Lung, and Blood Institute Workshop. Circulation 2011;124(10):1172–1179. Crossref, Medline, Google Scholar8 Klarich KW, Christian TF, Higano ST, Gibbons RJ. Variability of myocardium at risk for acute myocardial infarction. Am J Cardiol 1999;83(8):1191–1195. Crossref, Medline, Google Scholar9 Christian TF, Gibbons RJ, Clements IP, Berger PB, Selvester RH, Wagner GS. Estimates of myocardium at risk and collateral flow in acute myocardial infarction using electrocardiographic indexes with comparison to radionuclide and angiographic measures. J Am Coll Cardiol 1995;26(2):388–393. Crossref, Medline, Google Scholar10 Gibbons RJ. Tc-99m SPECT sestamibi for the measurement of infarct size. J Cardiovasc Pharmacol Ther 2011;16(3-4):321–331. Crossref, Medline, Google Scholar11 Mahaffey KW, Puma JA, Barbagelata NA, et al.. Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction: results of a multicenter, randomized, placebo-controlled trial: the Acute Myocardial Infarction STudy of ADenosine (AMISTAD) trial. J Am Coll Cardiol 1999;34(6):1711–1720. Crossref, Medline, Google Scholar12 Ross AM, Gibbons RJ, Stone GW, Kloner RA, Alexander RW; AMISTAD-II Investigators. A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II). J Am Coll Cardiol 2005;45(11):1775–1780. Crossref, Medline, Google Scholar13 Kim RJ, Albert TS, Wible JH, et al.. Performance of delayed-enhancement magnetic resonance imaging with gadoversetamide contrast for the detection and assessment of myocardial infarction: an international, multicenter, double-blinded, randomized trial. Circulation 2008;117(5):629–637. Crossref, Medline, Google Scholar14 Reimer KA, Jennings RB. The changing anatomic reference base of evolving myocardial infarction: underestimation of myocardial collateral blood flow and overestimation of experimental anatomic infarct size due to tissue edema, hemorrhage and acute inflammation. Circulation 1979;60(4):866–876. Crossref, Medline, Google Scholar15 Buja LM, Willerson JT. Abnormalities of volume regulation and membrane integrity in myocardial tissue slices after early ischemic injury in the dog: effects of mannitol, polyethylene glycol, and propranolol. Am J Pathol 1981;103(1):79–95. Medline, Google Scholar16 Jennings RB, Schaper J, Hill ML, Steenbergen C, Reimer KA. Effect of reperfusion late in the phase of reversible ischemic injury: changes in cell volume, electrolytes, metabolites, and ultrastructure. Circ Res 1985;56(2):262–278. Crossref, Medline, Google Scholar17 Klem I, Kim RJ. Assessment of microvascular injury after acute myocardial infarction: importance of the area at risk. Nat Clin Pract Cardiovasc Med 2008;5(12):756–757. Crossref, Medline, Google Scholar18 Abdel-Aty H, Cocker M, Meek C, Tyberg JV, Friedrich MG. Edema as a very early marker for acute myocardial ischemia: a cardiovascular magnetic resonance study. J Am Coll Cardiol 2009;53(14):1194–1201. Crossref, Medline, Google Scholar19 Bragadeesh T, Jayaweera AR, Pascotto M, et al.. Post-ischaemic myocardial dysfunction (stunning) results from myofibrillar oedema. Heart 2008;94(2):166–171. Crossref, Medline, Google Scholar20 Payne AR, Berry C, Kellman P, et al.. Bright-blood T(2)-weighted MRI has high diagnostic accuracy for myocardial hemorrhage in myocardial infarction: a preclinical validation study in swine. Circ Cardiovasc Imaging 2011;4(6):738–745. Crossref, Medline, Google Scholar21 Arai AE, Pantely GA, Anselone CG, Bristow J, Bristow JD. Active downregulation of myocardial energy requirements during prolonged moderate ischemia in swine. Circ Res 1991;69(6):1458–1469. Crossref, Medline, Google Scholar22 Natanzon A, Aletras AH, Hsu LY, Arai AE. Determining canine myocardial area at risk with manganese-enhanced MR imaging. Radiology 2005;236(3):859–866. Link, Google Scholar23 Fieno DS, Kim RJ, Chen EL, Lomasney JW, Klocke FJ, Judd RM. Contrast-enhanced magnetic resonance imaging of myocardium at risk: distinction between reversible and irreversible injury throughout infarct healing. J Am Coll Cardiol 2000;36(6):1985–1991. Crossref, Medline, Google Scholar24 Christian TF, Aletras AH, Arai AE. Estimation of absolute myocardial blood flow during first-pass MR perfusion imaging using a dual-bolus injection technique: comparison to single-bolus injection method. J Magn Reson Imaging 2008;27(6):1271–1277. Crossref, Medline, Google Scholar25 Christian TF, O'Connor MK, Schwartz RS, Gibbons RJ, Ritman EL. Technetium-99m MIBI to assess coronary collateral flow during acute myocardial infarction in two closed-chest animal models. J Nucl Med 1997;38(12):1840–1846. Medline, Google Scholar26 The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I findings. TIMI Study Group. N Engl J Med 1985;312(14):932–936. Medline, Google Scholar27 Berry C, Kellman P, Mancini C, et al.. Magnetic resonance imaging delineates the ischemic area at risk and myocardial salvage in patients with acute myocardial infarction. Circ Cardiovasc Imaging 2010;3(5):527–535. Crossref, Medline, Google Scholar28 Mewton N, Rapacchi S, Augeul L, et al.. Determination of the myocardial area at risk with pre- versus post-reperfusion imaging techniques in the pig model. Basic Res Cardiol 2011;106(6):1247–1257. Crossref, Medline, Google Scholar29 Ugander MBP, Oki AJ, Chen B, et al.. Quantitative T1-maps delineate myocardium at risk as accurately as T2-maps: experimental validation with microspheres. In: 2011 Scientific Sessions of the Society of Cardiovascular Magnetic Resonance and the EuroCMR. Nice, France, 2010. Google Scholar30 Abdel-Aty H, Zagrosek A, Schulz-Menger J, et al.. Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction. Circulation 2004;109(20):2411–2416. Crossref, Medline, Google Scholar31 Friedrich MG, Abdel-Aty H, Taylor A, Schulz-Menger J, Messroghli D, Dietz R. The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance. J Am Coll Cardiol 2008;51(16):1581–1587. Crossref, Medline, Google Scholar32 Carlsson M, Ubachs JF, Hedström E, Heiberg E, Jovinge S, Arheden H. Myocardium at risk after acute infarction in humans on cardiac magnetic resonance: quantitative assessment during follow-up and validation with single-photon emission computed tomography. JACC Cardiovasc Imaging 2009;2(5):569–576. Crossref, Medline, Google Scholar33 Graham MM, Faris PD, Ghali WA, et al.. Validation of three myocardial jeopardy scores in a population-based cardiac catheterization cohort. Am Heart J 2001;142(2):254–261. Crossref, Medline, Google Scholar34 Wince WB, Kim RJ. Molecular imaging: T2-weighted CMR of the area at risk: a risky business? Nat Rev Cardiol 2010;7(10):547–549. Crossref, Medline, Google Scholar35 Kim RJ, Fieno DS, Parrish TB, et al.. Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation 1999;100(19):1992–2002. Crossref, Medline, Google Scholar36 Kim RJ, Judd RM, Chen EL, Fieno DS, Parrish TB, Lima JA. Relationship of elevated 23Na magnetic resonance image intensity to infarct size after acute reperfused myocardial infarction. Circulation 1999;100(2):185–192. Crossref, Medline, Google Scholar37 Kim RJ, Wu E, Rafael A, et al.. The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. N Engl J Med 2000;343(20):1445–1453. Crossref, Medline, Google Scholar38 Choi KM, Kim RJ, Gubernikoff G, Vargas JD, Parker M, Judd RM. Transmural extent of acute myocardial infarction predicts long-term improvement in contractile function. Circulation 2001;104(10):1101–1107. Crossref, Medline, Google Scholar39 Ricciardi MJ, Wu E, Davidson CJ, et al.. Visualization of discrete microinfarction after percutaneous coronary intervention associated with mild creatine kinase-MB elevation. Circulation 2001;103(23):2780–2783. Crossref, Medline, Google Scholar40 Mahrholdt H, Wagner A, Holly TA, et al.. Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging. Circulation 2002;106(18):2322–2327. Crossref, Medline, Google Scholar41 Rehwald WG, Fieno DS, Chen EL, Kim RJ, Judd RM. Myocardial magnetic resonance imaging contrast agent concentrations after reversible and irreversible ischemic injury. Circulation 2002;105(2):224–229. Crossref, Medline, Google Scholar42 Mahrholdt H, Wagner A, Parker M, et al.. Relationship of contractile function to transmural extent of infarction in patients with chronic coronary artery disease. J Am Coll Cardiol 2003;42(3):505–512. Crossref, Medline, Google Scholar43 Wagner A, Mahrholdt H, Holly TA, et al.. Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet 2003;361(9355):374–379. Crossref, Medline, Google Scholar44 Matsumoto H, Matsuda T, Miyamoto K, Shimada T, Mikuri M, Hiraoka Y. Peri-infarct zone on early contrast-enhanced CMR imaging in patients with acute myocardial infarction. JACC Cardiovasc Imaging 2011;4(6):610–618. Crossref, Medline, Google Scholar45 Arai AE. Gadolinium can depict area at risk and myocardial infarction: a double-edged sword? JACC Cardiovasc Imaging 2011;4(6):619–621. Crossref, Medline, Google Scholar46 Kim RJ, Chen EL, Lima JA, Judd RM. Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after acute reperfused infarction. Circulation 1996;94(12):3318–3326. Crossref, Medline, Google Scholar47 Kramer CM, Rogers WJ, Mankad S, Theobald TM, Pakstis DL, Hu YL. Contractile reserve and contrast uptake pattern by magnetic resonance imaging and functional recovery after reperfused myocardial infarction. J Am Coll Cardiol 2000;36(6):1835–1840. Crossref, Medline, Google Scholar48 Oshinski JN, Yang Z, Jones JR, Mata JF, French BA. Imaging time after Gd-DTPA injection is critical in using delayed enhancement to determine infarct size accurately with magnetic resonance imaging. Circulation 2001;104(23):2838–2842. Crossref, Medline, Google Scholar49 Judd RM, Kim RJ. Imaging time after Gd-DTPA injection is critical in using delayed enhancement to determine infarct size accurately with magnetic resonance imaging. Circulation 2002;106(2):e6; author reply e6. Crossref, Medline, Google Scholar50 Sörensson P, Heiberg E, Saleh N, et al.. Assessment of myocardium at risk with contrast enhanced steady-state free precession cine cardiovascular magnetic resonance compared to single-photon emission computed tomography. J Cardiovasc Magn Reson 2010;12(1):25. Crossref, Medline, Google Scholar51 Friedrich MG, Kim HW, Kim RJ. T2-weighted imaging to assess post-infarct myocardium at risk. JACC Cardiovasc Imaging 2011;4(9):1014–1021. Crossref, Medline, Google Scholar52 Reimer KA, Jennings RB. The "wavefront phenomenon" of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow. Lab Invest 1979;40(6):633–644. Medline, Google Scholar53 Reimer KA, Lowe JE, Rasmussen MM, Jennings RB. The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation 1977;56(5):786–794. Crossref, Medline, Google Scholar54 Ubachs JF, Engblom H, Erlinge D, et al.. Cardiovascular magnetic resonance of the myocardium at risk in acute reperfused myocardial infarction: comparison of T2-weighted imaging versus the circumferential endocardial extent of late gadolinium enhancement with transmural projection. J Cardiovasc Magn Reson 2010;12:18. Crossref, Medline, Google Scholar55 Fuernau G, Eitel I, Franke V, et al.. Myocardium at risk in ST-segment elevation myocardial infarction comparison of T2-weighted edema imaging with the MR-assessed endocardial surface area and validation against angiographic scoring. JACC Cardiovasc Imaging 2011;4(9):967–976. Crossref, Medline, Google Scholar56 Versteylen MO, Bekkers SC, Smulders MW, et al.. Performance of angiographic, electrocardiographic and MRI methods to assess the area at risk in acute myocardial infarction. Heart 2012;98(2):109–115. Crossref, Medline, Google Scholar57 Hsu LY, Ingkanisorn WP, Kellman P, Aletras AH, Arai AE. Quantitative myocardial infarction on delayed enhancement MRI. II. Clinical application of an automated feature analysis and combined thresholding infarct sizing algorithm. J Magn Reson Imaging 2006;23(3):309–314. Crossref, Medline, Google Scholar58 Hsu LY, Natanzon A, Kellman P, Hirsch GA, Aletras AH, Arai AE. Quantitative myocardial infarction on delayed enhancement MRI. I. Animal validation of an automated feature analysis and combined thresholding infarct sizing algorithm. J Magn Reson Imaging 2006;23(3):298–308. Crossref, Medline, Google Scholar59 Simonetti OP, Finn JP, White RD, Laub G, Henry DA. "Black blood" T2-weighted inversion-recovery MR imaging of the heart. Radiology 1996;199(1):49–57. Link, Google Scholar60 Aletras AH, Kellman P, Derbyshire JA, Arai AE. ACUT2E TSE-SSFP: a hybrid method for T2-weighted imaging of edema in the heart. Magn Reson Med 2008;59(2):229–235. Crossref, Medline, Google Scholar61 Ortiz-Pérez JT, Meyers SN, Lee DC, et al.. Angiographic estimates of myocardium at risk during acute myocardial infarction: validation study using cardiac magnetic resonance imaging. Eur Heart J 2007;28(14):1750–1758. Crossref, Medline, Google Scholar62 Wright J, Adriaenssens T, Dymarkowski S, Desmet W, Bogaert J. Quantification of myocardial area at risk with T2-weighted CMR: comparison with contrast-enhanced CMR and coronary angiography. JACC Cardiovasc Imaging 2009;2(7):825–831. Crossref, Medline, Google Scholar63 Hedström E, Engblom H, Frogner F, et al.. Infarct evolution in man studied in patients with first-time coronary occlusion in comparison to different species: implications for assessment of myocardial salvage. J Cardiovasc Magn Reson 2009;11:38. Crossref, Medline, Google Scholar64 Giri S, Chung YC, Merchant A, et al.. T2 quantification for improved detection of myocardial edema. J Cardiovasc Magn Reson 2009;11:56. Crossref, Medline, Google Scholar65 Arai AE, Epstein FH, Bove KE, Wolff SD. Visualization of aortic valve leaflets using black blood MRI. J Magn Reson Imaging 1999;10(5):771–777. Crossref, Medline, Google ScholarArticle HistoryReceived November 21, 2011; revision requested December 27; revision received January 23, 2012; accepted March 29; final version accepted April 23.Published online: Oct 2012Published in print: Oct 2012 FiguresReferencesRelatedDetailsCited BySingle breath‐hold three‐dimensional whole‐heart T 2 mapping with low‐rank plus sparse reconstructionDongyueSi, XiangchuangKong, RuiGuo, LanCheng, ZihanNing, ZhensenChen, ShuoChen, Daniel A.Herzka, HaiyanDing27 March 2023 | NMR in Biomedicine, Vol. 36, No. 8MRI for measuring therapy efficiency after revascularisation in ST-segment elevation myocardial infarction: a systematic review and meta-regression analysisBenjaminKendziora, HeliStier, PeterSchlattmann, MarcDewey28 September 2020 | BMJ Open, Vol. 10, No. 9Prognostic value of the myocardial salvage index measured by T2-weighted and T1-weighted late gadolinium enhancement magnetic resonance imaging after ST-segment elevation myocardial infarction: A systematic review and meta-regression analysisBenjaminKendziora, MarcDewey, IfyMordi13 February 2020 | PLOS ONE, Vol. 15, No. 2Measuring extracellular volume fraction by MRI: First verification of values given by clinical sequencesDavidNordlund, ChristosXanthis, SebastianBidhult, RobertJablonowski, MikaelKanski, SaschaKopic, MarcusCarlsson, HenrikEngblom, Anthony H.Aletras, HåkanArheden16 August 2019 | Magnetic Resonance in Medicine, Vol. 83, No. 2EVCMR: A tool for the quantitative evaluation and visualization of cardiac MRI dataYoon-ChulKim, Khu RaiKim, KwangheeChoi, MinwooKim, YounjoonChung, Yeon HyeonChoe2019Aug1 | Computers in Biology and Medicine, Vol. 111Cardiovascular magnetic resonance techniques for tissue characterization after acute myocardial injuryAhmetDemirkiran, HenkEveraars, Raquel PAmier, CasperBeijnink, Michiel JBom, Marco J WGötte, Ramon Bvan Loon, Jasper LSelder, Albert Cvan Rossum, RobinNijveldt25 May 2019 | European Heart Journal - Cardiovascular Imaging, Vol. 20, No. 7Assessment of the myocardial area at risk: comparing T2-weighted cardiovascular magnetic resonance imaging with contrast-enhanced cine (CE-SSFP) imaging—a DANAMI3 substudyChristofferGöransson, Kiril AleksovAhtarovski, KasperKyhl, JacobLønborg, LarsNepper-Christensen, LittenBertelsen, Adam AliGhotbi, Mikkel MalbySchoos, LarsKøber, DanHøfsten, SteffenHelqvist, HenningKelbæk, ThomasEngstrøm, NielsVejlstrup31 July 2018 | European Heart Journal - Cardiovascular Imaging, Vol. 20, No. 3Acute Myocardial InfarctionAndrewArai2019Jan1Myocardial Salvage Imaging: Where Are We and Where Are We Heading? 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