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A convenient synthesis of psoralens

2002; Elsevier BV; Volume: 58; Issue: 24 Linguagem: Inglês

10.1016/s0040-4020(02)00441-6

1464-5416

Stefano Chimichi, Marco Boccalini, Barbara Cosimelli, Giampietro Viola, Daniela Vedaldi, Francesco Dall’Acqua,

Bioactive Compounds and Antitumor Agents

An efficient synthesis (yields >70%) of linear 7H-furo[3,2-g]chromen-7-one derivatives (psoralens or furocoumarins) has been carried out starting from ring-substituted 2-(coumarin-7-yl)oxyaldehydes; moreover, the phototoxicity of these compounds has been tested on a cultured cell line of murine fibroblast.