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An Unexpected Bis-ligation of S -Nitrosothiols

2009; American Chemical Society; Volume: 131; Issue: 11 Linguagem: Inglês

10.1021/ja900370y

1943-2984

Jiming Zhang, Hua Wang, Ming Xian,

Synthesis and Catalytic Reactions

A bis-ligation reaction of S-nitrosothiols using triaryl substituted phosphine-thioester substrates has been developed. This reaction converts unstable primary S-nitrosothiols to stable disulfide-iminophosphorane products in high yields under mild conditions. It can potentially be applied for the detection of S-nitrosation in protein systems.