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Treatment of Haemochromatosis by Repeated Venesection

1954; BMJ; Volume: 2; Issue: 4903 Linguagem: Inglês

10.1136/bmj.2.4903.1511

0959-8138

Deborah Davey, A. W. H. Foxell, T. A. Kemp,

Iron Metabolism and Disorders

MEDICAL JOURNALIsoniazid-resistant organisms were isolated at some time from about one-half the patients in the T1H and the T2H groups and from about two-thirds in the H group; but in the T5H group resistant organisms were obtained from only 3 out of the 10 patients, and in none before the end of the fifth month of treatment.No oxytetracycline resistance was encountered.There was no important difference between the four treatment groups as regards clinical or radiological pro- gress over the first three months of treatment.Treatment of one patient in the T5H group had to be stopped after one week because of intractable diarrhoea and vomiting.Apart from this, the toxic effects attributable to oxytetracycline were slight.Owing to the considerable incidence of isoniazid resistance in the T1H and T2H groups, neither method can be recommended as satisfactory in treatment.On the other hand, oxytetracycline in a dosage of 5 g.daily would seem to be of probable value in delaying or pre- venting the onset of isoniazid resistance, but this com- bination is likely to be less effective than that of strepto- mycin or P.A.S. with isoniazid; it is also very expensive.