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Hybrid polarizing solids for pure hyperpolarized liquids through dissolution dynamic nuclear polarization

2014; National Academy of Sciences; Volume: 111; Issue: 41 Linguagem: Inglês

10.1073/pnas.1407730111

1091-6490

David Gajan, Aurélien Bornet, Basile Vuichoud, Jonas Milani, Roberto Melzi, Henri A. van Kalkeren, Laurent Veyre, Chloé Thieuleux, Matthew P. Conley, W Grüning, Martin Schwarzwälder, Anne Lesage, Christophe Copéret, Geoffrey Bodenhausen, Lyndon Emsley, Sami Jannin,

Electron Spin Resonance Studies

Significance Hyperpolarization by dissolution dynamic nuclear polarization can dramatically enhance signal intensities in MRI and NMR, notably for metabolic tracers for imaging and diagnosis. It is applicable to a variety of substrates for in vivo imaging and chemistry but requires the use of contaminants (glassing agents and free radicals) that may interact with cells and proteins and can have potential side effects. These contaminants can sometimes be eliminated by precipitation followed by filtration or solvent extraction, but these methods are substrate-specific, are usually time-consuming, and typically result in signal loss. Here, production of pure hyperpolarized liquids free of contaminants is shown by a simple wetting–polarization–filtration sequence for a solid silica matrix containing homogeneously distributed persistent radicals.