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Immunohistologic Findings and Results of Treatment with Cyclosporine in Ligneous Conjunctivitis

1989; Elsevier BV; Volume: 107; Issue: 2 Linguagem: Inglês

10.1016/0002-9394(89)90216-x

1879-1891

Edward J. Holland, Chi‐Chao Chan, Toichiro Kuwabara, Alan G. Palestine, J. James Rowsey, Robert B. Nussenblatt,

Ocular Diseases and Behçet’s Syndrome

Using immunohistochemical techniques, we studied ligneous conjunctival lesions from two patients. A significant immune reaction was detected that was characterized by activated T lymphocytes and focal accumulation of plasma cells and B lymphocytes. Immunofluorescent studies demonstrated that IgG was a prominent component of the amorphous hyaline material seen in these lesions. After previous treatment methods had failed, both patients were treated with ex-cisional biopsy and topical cyclosporine. Patient 1 had a dramatic response, with complete resolution of the lesions. Patient 2 had a significant improvement resulting in small, slow-growing recurrences instead of the rapid and extensive recurrences that occurred before treatment with cyclosporine.