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Clinical Applications of Magnetic Drug Targeting

2001; Elsevier BV; Volume: 95; Issue: 2 Linguagem: Inglês

10.1006/jsre.2000.6030

1095-8673

Andreas S. Lübbe, Christoph Alexiou, Christian Bergemann,

Cancer Treatment and Pharmacology

Cancer patients often present with localized disease. Yet, surgical eradication or radiation treatment is not always possible or meaningful. Site-directed drug targeting is one way of local or regional antitumor treatment. Magnetically controlled drug targeting is one of the various possibilities of drug targeting. This technology is based on binding established anticancer drugs with ferrofluids that concentrate the drug in the area of interest (tumor site) by means of magnetic fields. Then, the drug desorbs from the ferrofluid and enfolds its mechanism of action. This paper gives the reader an overview of current applications of ferrofluids (magnetic liquids) in conjunction with magnetic fields as they relate to the latest advances in medical applications and in particular to anticancer treatment.