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Solid-Phase Synthesis of Peptidomimetic Inhibitors for the Hepatitis C Virus NS3 Protease

2001; American Chemical Society; Volume: 66; Issue: 14 Linguagem: Inglês

10.1021/jo010164d

1520-6904

Marc‐André Poupart, Dale R. Cameron, Catherine Chabot, Élise Ghiro, Nathalie Goudreau, Sylvie Goulet, Martin Poirier, Youla S. Tsantrizos,

Hepatitis C virus research

The NS3 serine protease enzyme of the hepatitis C virus (HCV) is essential for viral replication. Short peptides mimicking the N-terminal substrate cleavage products of the NS3 protease are known to act as weak inhibitors of the enzyme and have been used as templates for the design of peptidomimetic inhibitors. Automated solid-phase synthesis of a small library of compounds based on such a peptidomimetic scaffold has led to the identification of potent and highly selective inhibitors of the NS3 protease enzyme.