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Catalyst-free reactions under solvent-free conditions: microwave-assisted synthesis of heterocyclic hydrazones below the melting points of neat reactants

2001; Royal Society of Chemistry; Issue: 18 Linguagem: Inglês

10.1039/b104508n

1364-548X

Marjan Ješelnik, Slovenko Polanc, Marijan Kočevar, Rajender S. Varma,

Synthesis and biological activity

The reaction of neat 5- or 8-oxobenzopyran-2(1H)-ones, 1-3, with a variety of aromatic and heteroaromatic hydrazines, 4, is remarkably accelerated upon irradiation in a household microwave oven in the absence of any catalyst, solid support or solvent thus providing an environmentally friendly route to several heterocyclic hydrazones.