Acyl coenzyme a inhibition of Leuconostoc mesenteroides glucose-6-phosphate dehydrogenase: A comparison of the TPN and DPN linked reactions
1973; Elsevier BV; Volume: 53; Issue: 1 Linguagem: Inglês
10.1016/0006-291x(73)91401-0
ISSN1090-2104
AutoresElmon L. Coe, Lung-Hsiung Hsu,
Tópico(s)Pneumocystis jirovecii pneumonia detection and treatment
ResumoThe inhibitory effects of ATP, coenzyme A, and acetyl, malonyl, and oleyl derivatives of coenzyme A on the TPN and DPN dependent activities of Leuconostoc glucose-6-phosphate dehydrogenase are compared. At pH 7.8, 24°, saturating levels of DPN or TPN, and inhibitor concentrations of 2–4 mM only ATP has an appreciable effect on the TPN dependent reaction, but all were potent inhibitors of the DPN dependent reaction. Oleyl coenzyme A was the most effective (Ki ∼ 0.15 mM against glucose-6-phosphate) while acetyl coenzyme A was least effective (Ki ∼ 1.0 mM). A possible regulatory role of this inhibition in fatty acid synthesis is suggested.
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