Progressive lymph node histology and its prognostic value in patients with acquired immunodeficiency syndrome and AIDS-related complex
1989; Elsevier BV; Volume: 20; Issue: 6 Linguagem: Inglês
10.1016/0046-8177(89)90247-5
ISSN1532-8392
AutoresAmy Chadburn, Craig E. Metroka, Janet Mouradian,
Tópico(s)HIV Research and Treatment
ResumoSeventy-four sequential lymph node biopsies from 30 acquired immunodeficiency syndrome (AIDS)/AIDS-related complex (ARC) patients showed temporal histologic progression from explosive follicular hyperplasia (EFH) to mixed follicular hyperplasia/involution (mixed) to follicular involution (FI) to lymphocyte depletion (LD). This histologic progression correlated with symptoms, development of opportunistic infections (OI), and mortality. An initial biopsy, only 50% of the AIDS/ARC patients with EFH/mixed compared to 100% with FILD were symptomatic with weight loss, night sweats, diarrhea, fever, or fatigue. 31% of ARC patients with EFH and 63% with FI developed an OI in a median of 69 months and 5 months, respectively; 86% with LD had a concurrent or previous OI. Ninety percent of ARC patients progressing to FILD died; 85% of those persisting with EFH/mixed remained alive 18 to 50 months after initial biopsy. AIDS patients with EFH lived twice as long as those with FILD. Progressive histology did not correlate with lymphoma. The number of ARC patients developing Kaposi's sarcoma was too small to draw definitive conclusions.
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