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BIBTEX RIS

What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells?

2004; Elsevier BV; Volume: 6; Issue: 6 Linguagem: Inglês

10.1016/j.micinf.2004.02.012

1769-714X

Karina R. B. Bastos, Cláudio Romero Farias Marinho, Renato Barboza, Momtchilo Russo, José María Álvarez, Maria Regina D’Império Lima,

Immune Response and Inflammation

The present review illustrates the current knowledge on the autocrine effect of IL-12, and the putative contribution of IL-23, on macrophages and dendritic cells, focusing on cell activation and microbicidal activity. Here, we present convincing evidence that IL-12 is not only a connective element between accessory cells and lymphocytes, but it is also a key molecule for programming the macrophage and dendritic cell functions.