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The unprecedented synthesis of novel spiro-1,2,4-triazolidinones

2013; Royal Society of Chemistry; Volume: 3; Issue: 48 Linguagem: Inglês

10.1039/c3ra44641g

2046-2069

Dattaprasad M. Pore, Pravin G. Hegade, Mansing M. Mane, Jayavant D. Patil,

Synthesis and Characterization of Heterocyclic Compounds

Glycine nitrate mediated an environmentally benign, simple method which is reported for synthesis of novel spiro-1,2,4-triazolidinones from isatin and semicarbazide/thiosemicarbazide in water with excellent yields. Unexpected formation of novel spiro-1,2,4-triazolidinones instead of [1,2,4]-triazino derivatives is observed. Moreover, the method is applicable for a variety of isatins. Rapid eco-friendly reactions with high yields, easy work-up procedure as well as isolation of product, excellent catalyst recyclability, high atom economy, and novelty are the auxiliary advantages of the protocol.