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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Seroprevalence of human herpesvirus‐8 in blood donors from different geographical regions of Argentina, Brazil, and Chile

2004; Wiley; Volume: 72; Issue: 4 Linguagem: Inglês

10.1002/jmv.20029

ISSN

1096-9071

Autores

Celeste Pérez, Mònica Tous, Sandra Gallego, Norma Zala, Oscar Rabinovich, Susana Garbiero, María José Martínez, Andréa Mendonça Gusmão Cunha, Sofía Camino, Alicia Cámara Muñoz, Sandra Cecı́lia Botelho Costa, Milton Larrondo, Verónica Francalancia, Fernando Landreau, Miguel Bartomioli,

Tópico(s)

HIV Research and Treatment

Resumo

Human herpesvirus-8 (HHV-8) causes Kaposi's sarcoma (KS) and lymphoproliferative disorders in both HIV-infected and uninfected patients. HHV-8 has a worldwide occurrence but infection rates vary according to a combination of geographic and behavioral risks. The main transmission route seems to be sexual, nevertheless, nasal secretions, saliva, blood, and organ graft have been proposed. HHV-8 was postulated as a new infectious agent for screening in blood donors. The aim of this study was to evaluate the prevalence of antibodies against HHV-8 antigens in blood donors of South America. Serum samples from 2,470 blood donors from Argentina, Brazil, and Chile corresponding to five geographic regions were studied by indirect immunofluorescence assay (IFA). Seroprevalence rate was 3.7% (92/2,470; 95% CI 2.9-4.5) in the entire blood donor population distributed as follows: Argentina, 4.0% (Buenos Aires city, 4.3%; Bahia Blanca, 2.4%; and Córdoba, 4.0%), Campinas (Brazil), 2.8%; and Santiago de Chile, 3.0%. There was no difference (P>0.05) between men and women or age related, except in Brazil where positive cases were 30-49-year-old males. The present study, which includes different geographical areas of multiple countries from South America, has not been done before. The results show similar prevalence rates among the studied zones corresponding to low-prevalence regions. South America is a large sub-continent with a wide spectrum of population and geographical characteristics, thus, more HHV-8 prevalence studies should be necessary to establish possible regional differences.

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