Serotonin-induced hypoglycemia and increased serum insulin levels in mice
1989; Elsevier BV; Volume: 45; Issue: 20 Linguagem: Inglês
10.1016/0024-3205(89)90547-x
ISSN1879-0631
AutoresJun Yamada, Yumi Sugimoto, Ikuko Kimura, Naoko Takeuchi, Kazuyoshi Horisaka,
Tópico(s)Receptor Mechanisms and Signaling
ResumoThe effects of serotonin (5-HT) on plasma glucose levels were studied. 5-HT above 20 mg/kg induced apparent hypoglycemia in mice. The hypoglycemic effects of 5-HT were strongly antagonized by methysergide but only partially inhibited by ketanserin. However, ICS 205-930 was without effect. This indicates that the hypoglycemia induced by 5-HT is mediated by both the 5-HT1 and 5-HT2 receptors. 5-HT also produced an increase in serum immunoreactive insulin (IRI) which was completely inhibited by methysergide and partially antagonized by ketanserin. It is suggested that the 5-HT-induced increase in IRI is elicited by the activation of the 5-HT1 and 5-HT2 receptors, which is similar to the results obtained with plasma glucose. These results indicate that the 5-HT receptors may regulate blood glucose levels by modifying the release of insulin.
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