Anodic cyclization reactions and the synthesis of (−)-crobarbatic acid
2008; Elsevier BV; Volume: 49; Issue: 24 Linguagem: Inglês
10.1016/j.tetlet.2008.04.075
ISSN1873-3581
AutoresHai‐Chao Xu, John D. Brandt, Kevin D. Moeller,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoAbstract A synthesis of (−)-crobarbatic acid is reported along with the first use of a vinyl-substituted ketene dithioacetal as a coupling partner for an anodic cyclization reaction. The use of the vinyl-substituted ketene dithioacetal enables the construction of a cyclic product having a tetrasubstituted carbon with a relative stereochemistry opposite to that originally obtained from the cyclization.
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