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β-arrestins: traffic cops of cell signaling

2004; Elsevier BV; Volume: 16; Issue: 2 Linguagem: Inglês

10.1016/j.ceb.2004.01.001

1879-0410

Robert J. Lefkowitz, Erin J. Whalen,

Chemokine receptors and signaling

Once thought to function only in the desensitization of seven membrane spanning receptors (7MSRs), the ubiquitous β-arrestin molecules are increasingly appreciated to play important roles in the endocytosis and signaling of these receptors. These functions reflect the ability of the β-arrestins to bind an ever-growing list of signaling and endocytic elements, often in an agonist-dependent fashion. One heavily studied system is that leading to MAP kinase activation via β-arrestin-mediated scaffolding of these pathways in a receptor-dependent fashion. The β-arrestins are also found to be involved in the regulation of novel receptor systems, such as Frizzled and TGFβ receptors.