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A System for Cerebral Blood Flow Measurement Using an H 2 15 O Autoradiographic Method and Positron Emission Tomography

1987; SAGE Publishing; Volume: 7; Issue: 2 Linguagem: Inglês

10.1038/jcbfm.1987.37

1559-7016

Iwao Kanno, Hidehiro Iida, Shuichi Miura, M.T. Murakami, Kazuhiro Takahashi, Hiroshi Sasaki, A Inugami, F Shishido, Kazuki Uemura,

Lanthanide and Transition Metal Complexes

A system for CBF measurement using an H 2 15 O autoradiographic method and positron emission tomography (PET) has been designed and installed as a clinical tool. Following an intravenous injection of H 2 15 O, a radioactivity accumulation in the brain tissue for 60 s and a continuous record of radioactivity in arterial blood were measured by a high counting speed PET device and a beta-ray detector, respectively, and CBF was calculated by a table-lookup procedure. First, this method was compared with the C 15 O 2 inhalation steady-state method on 17 cerebrovascular disease patients and four normal subjects. The two values for CBF agreed with each other when H 2 15 O autoradiographic method was applied by correction for the dispersion in the measured arterial radioactivity–time curve. However, without the correction, the CBF by the H 2 15 O autoradiographic method revealed substantial overestimation by 30.6 ± 17.5%. A reduced gray/white ratio of CBF was also observed in the H 2 15 O autoradiographic method. Second, simulation was performed in order to determine optimal accumulation time by PET scan; the result was that errors due to dispersion and time mismatch became critical as the accumulation time was shortened to <60 s.