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Proline in fascioliasis—IV induction of bile duct hyperplasia

1978; Elsevier BV; Volume: 61; Issue: 2 Linguagem: Inglês

10.1016/0300-9629(78)90104-4

0300-9629

Joseph T. Sawma, Hadar Isseroff, David Reino,

Parasite Biology and Host Interactions

1. Rats were implanted with cannulae in the abdominal cavity and infused with one of the following solutions: saline; 20.0 mM proline in saline, or saline containing alanine, valine, methionine, leucine, tyrosine, phenylalanine and histidine each at 2.0 mM. 2. Comparison of the lumenal perimeters in the bile ducts of the infused animals revealed that a significant hyperplasia was induced by proline; none of the other amino acids tested was effective. 3. Histologically, the proline-induced hyperplasia resembles that observed in bile ducts from rats infected with Fasciola hepatica.