Acute versus chronic graft rejection: Related manifestations of allosensitization in graft recipients
1997; Elsevier BV; Volume: 11; Issue: 1 Linguagem: Inglês
10.1016/s0955-470x(97)80036-5
ISSN1557-9816
AutoresCharles G. Orosz, Sergio D. Bergese, Elaine Wakely, Dongyuan Xia, Gayle M. Gordillo, Anne M. VanBuskirk,
Tópico(s)Parvovirus B19 Infection Studies
ResumoVillitis of unknown etiology (VUE) is an inflammatory disease characterized by the infiltration of maternal CD8 +T cells into the placental villi. Although the pathogenesis of VUE is still debated, dysregulation of the immune system appears to be an important factor in the development of the disease. Interaction of maternal T cells with the fetal antigens seems to be the trigger for the VUE onset. In this context, graft vs host disease (GVHD) and allographic rejection seem to share similarities in the VUE immunopathological mechanism, especially those related to immunoregulation. In this review, we compared the immunological characteristics of VUE with allograft rejection, and GVHD favoring a better knowledge of VUE pathogenesis that may contribute to VUE therapeutics strategies in the future.
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