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A study of the inhibition of tumor growth in mice and rats with azo compounds

1952; Wiley; Volume: 5; Issue: 3 Linguagem: Inglês

10.1002/1097-0142(195205)5

1097-0142

Arnold M. Seligman, Ralph M. Gofstein, Orrie M. Friedman,

Computational Drug Discovery Methods

CancerVolume 5, Issue 3 p. 613-619 ArticleFree Access A study of the inhibition of tumor growth in mice and rats with azo compounds Arnold M. Seligman M.D., Arnold M. Seligman M.D. Kirstein Laboratory for Surgical Research, Beth Israel Hospital, the Department of Surgery, Harvard Medical School, Boston, and the Chemical Laboratory of Harvard University, Cambridge, MassachusettsSearch for more papers by this authorRalph M. Gofstein M.D., Ralph M. Gofstein M.D. Kirstein Laboratory for Surgical Research, Beth Israel Hospital, the Department of Surgery, Harvard Medical School, Boston, and the Chemical Laboratory of Harvard University, Cambridge, MassachusettsSearch for more papers by this authorOrrie M. Friedman Ph.D., Orrie M. Friedman Ph.D. Kirstein Laboratory for Surgical Research, Beth Israel Hospital, the Department of Surgery, Harvard Medical School, Boston, and the Chemical Laboratory of Harvard University, Cambridge, MassachusettsSearch for more papers by this author Arnold M. Seligman M.D., Arnold M. Seligman M.D. Kirstein Laboratory for Surgical Research, Beth Israel Hospital, the Department of Surgery, Harvard Medical School, Boston, and the Chemical Laboratory of Harvard University, Cambridge, MassachusettsSearch for more papers by this authorRalph M. Gofstein M.D., Ralph M. Gofstein M.D. Kirstein Laboratory for Surgical Research, Beth Israel Hospital, the Department of Surgery, Harvard Medical School, Boston, and the Chemical Laboratory of Harvard University, Cambridge, MassachusettsSearch for more papers by this authorOrrie M. Friedman Ph.D., Orrie M. Friedman Ph.D. Kirstein Laboratory for Surgical Research, Beth Israel Hospital, the Department of Surgery, Harvard Medical School, Boston, and the Chemical Laboratory of Harvard University, Cambridge, MassachusettsSearch for more papers by this author First published: May 1952 https://doi.org/10.1002/1097-0142(195205)5:3 3.0.CO;2-ZCitations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Badger, G. M.; Elson, L. A.; Haddow, A.; Hewett, C. L., and Robinson, A. M.: The inhibition of growth by chemical compounds. Proc. Roy. Soc., London B 130: 255–299, 1941–1942. 2 Bamberger, E.: Ueber die Einwirkung von Diazobenzol auf Phenol und die Synthese des Orthooxyazobenzols. Ber. d. deutsch. chem. Gesellsch. 33: 3188–3192, 1900. 3 Belkin, M.: Effect of podophyllin on transplanted mouse tumors. J. Pharmacol. & Exper. Therap. 93: 18–25, 1948. 4 Borgoslovsky, B. M.: New method for the preparation of symmetrical aso [sic] compounds. J. Gen. Chem., U.S.S.R. 16: 193–197; Eng. summ. 197–198, 1946. 5 Colombano, A.: Eterificazione degli ossiazo composti per mezzo del solfato dimetilico. Gazz. chim. ital. 37 II: 471–482, 1907. 6 Cook, A. H., and Jones, J. G.: cis-Azo-compounds. Part IV. Some reactions with diphenyl ketene. J. Chem. Soc. London [1941]: 184–187, 1941. 7 Elson, L. A., and Haddow, A.: The inhibitory action of 1:2:5:6-dibenzanthracene on the growth of the Walker carcinoma 256 in rats maintained on high and low protein diets. Brit. J. Cancer 1: 97–101, 1947. 8 Elson, L. A., and Warren, F. L.: The relation between growth inhibition, toxicity and protein metabolism in rats treated with 1:2:5:6-dibenzanthracene. Brit. J. Cancer 1: 86–97, 1947. 9 Friedman, O. M.; Gofstein, R. M., and Seligman, A. M.: Preparation of azo compounds for the study of inhibition of tumor growth. J. Am. Chem. Soc. 71: 3010–3013, 1949. 10 Haddow, A.: Influence of certain polycyclic hydrocarbons on the growth of the Jensen rat sarcoma. Nature, London 136: 868–869, 1935. 11 Haddow, A.: The influence of carcinogenic compounds and related substances on the rate of growth of spontaneous tumours of the mouse. J. Path. and Bact. 47: 567–579, 1938. 12 Haddow, A., and Robinson, A. M.: The influence of various polycyclic hydrocarbons on the growth rate of transplantable tumours. Proc. Roy. Soc., London B 122: 442–476, 1937. 13 Haddow, A., and Robinson, A. M.: The association of carcinogenicity and growth-inhibitory power in the polycyclic hydrocarbons and other substances. Proc. Roy. 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London [1895]: 925–933, 1895. 20 Nietzki, R., and Göttig, J.: Ueber das β-Azonaphthalin. Ber. d. deutsch. chem. Gesellsch. 20: 612–613, 1887. 21 Parsons, T., Jr., and Bailar, J. C., Jr.: The preparation of methyl substituted azobenzenes and azoxybenzenes and the rearrangement of methyl substituted azobenzenes. J. Am. Chem. Soc. 58: 268–271, 1936. 22 Seligman, A. M.; Milden, M., and Friedman, O. M.: A study of the inhibition of tumor growth in mice and rats with 10-methyl-1,2-benzanthracene and derivatives related to the nitrogen and sulfur beta-chloroethyl vesicants. Cancer 2: 701–706, 1949. 23 Stern, K., and Willheim, R.: The Biochemistry of Malignant Tumors. New York, Reference Press. 1946; pp. 236–239. 24 Vorländer, D., and Meyer, F.: Aromatische Diazoniumsalze und ammoniakalische Kupferoxydullösung. Ann. d. Chem. 320: 122–144, 1902. Citing Literature Volume5, Issue3May 1952Pages 613-619 ReferencesRelatedInformation