Portal de Periódicos da CAPES

Aspects of Astrocyte Energy Metabolism, Amino Acid Neurotransmitter Homoeostasis and Metabolic Compartmentation

2012; SAGE Publishing; Volume: 4; Issue: 3 Linguagem: Inglês

10.1042/an20120007

1759-0914

Marko Kreft, Lasse K. Bak, Helle S. Waagepetersen, Arne Schousboe,

Neuroinflammation and Neurodegeneration Mechanisms

Astrocytes are key players in brain function; they are intimately involved in neuronal signalling processes and their metabolism is tightly coupled to that of neurons. In the present review, we will be concerned with a discussion of aspects of astrocyte metabolism, including energy-generating pathways and amino acid homoeostasis. A discussion of the impact that uptake of neurotransmitter glutamate may have on these pathways is included along with a section on metabolic compartmentation.