α-Chlorination of ketones using p-toluenesulfonyl chloride
1999; Elsevier BV; Volume: 40; Issue: 12 Linguagem: Inglês
10.1016/s0040-4039(99)00213-0
ISSN1873-3581
AutoresKay M. Brummond, Kirsten D. Gesenberg,
Tópico(s)Oxidative Organic Chemistry Reactions
ResumoTreatment of a variety of ketones with lithium diisopropylamide followed by p-toluenesulfonyl chloride gives α-chloroketones in good yields. In addition, a polymer tosyl chloride reagent has also been shown to effect this transformation.
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